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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pirbtm1Ttk
targeted mutation 1, Toshiyuki Takai
MGI:2180757
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pirbtm1Ttk/Pirbtm1Ttk involves: 129X1/SvJ MGI:3041944


Genotype
MGI:3041944
hm1
Allelic
Composition		 Pirbtm1Ttk/Pirbtm1Ttk
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pirbtm1Ttk mutation (2 available); any Pirb mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell activation ( J:76770 )
• B cells are constitutively activated
increased B cell proliferation ( J:76770 )
• enhanced proliferative response of splenic B2 cells stimulated with anti IgM
abnormal T cell physiology ( J:76770 )
• T cell proliferation remains normal
abnormal T-helper 2 physiology ( J:76770 )
• enhanced T helper 2 dependent antibody responses
• augmented IgG1 and IgE responses
• increased production of Il-4 and decreased Ifn-gamma
abnormal dendritic cell differentiation ( J:76770 )
• dendritic cells remain immature
increased B-1 B cell number ( J:76770 )
• B1 cells were more abundant in older mice

hematopoietic system
abnormal dendritic cell differentiation ( J:76770 )
• dendritic cells remain immature
increased B-1 B cell number ( J:76770 )
• B1 cells were more abundant in older mice
abnormal B cell activation ( J:76770 )
• B cells are constitutively activated
increased B cell proliferation ( J:76770 )
• enhanced proliferative response of splenic B2 cells stimulated with anti IgM
abnormal T cell physiology ( J:76770 )
• T cell proliferation remains normal
abnormal T-helper 2 physiology ( J:76770 )
• enhanced T helper 2 dependent antibody responses
• augmented IgG1 and IgE responses
• increased production of Il-4 and decreased Ifn-gamma

cellular
abnormal dendritic cell differentiation ( J:76770 )
• dendritic cells remain immature
increased B cell proliferation ( J:76770 )
• enhanced proliferative response of splenic B2 cells stimulated with anti IgM




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory