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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd34tm1Lal
targeted mutation 1, Larry A Lasky
MGI:2180758
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd34tm1Lal/Cd34tm1Lal involves: 129S2/SvPas MGI:3845229


Genotype
MGI:3845229
hm1
Allelic
Composition
Cd34tm1Lal/Cd34tm1Lal
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd34tm1Lal mutation (0 available); any Cd34 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mean CFU isolated from yolk sacs is about half of controls
• high proliferative potential colony-forming cells is decreased by almost 70% in the bone marrow and 85% in the spleen
• mean CFU isolated from fetal liver is much less than controls
• CFU-GM is reduced by about 66% in the bone marrow and CFU-GEMM by 73%
• CFU-GM is reduced by 87% in the bone marrow and spleen
• CFU-GEMM is reduced by 78% in the blood
• mean BFU-E isolated from fetal liver is significantly less than controls
• BFU-E is reduced by 54% in the bone marrow and 78% in the spleen
• splenocyte number is 49% that of control

immune system
• splenocyte number is 49% that of control





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory