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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd3dtm1Kap
targeted mutation 1, Dietmar J Kappes
MGI:2180760
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd3dtm1Kap/Cd3dtm1Kap C57BL/6-Cd3dtm1Kap MGI:2651579


Genotype
MGI:2651579
hm1
Allelic
Composition		 Cd3dtm1Kap/Cd3dtm1Kap
Genetic
Background		 C57BL/6-Cd3dtm1Kap
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3dtm1Kap mutation (0 available); any Cd3d mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
arrested T cell differentiation ( J:39925 )
• block in alpha-beta T cell development; thymic selection is blocked at the transition from the double-positive to single-positive stages of development
• however, development of gamma-delta T cells is normal

hematopoietic system
arrested T cell differentiation ( J:39925 )
• block in alpha-beta T cell development; thymic selection is blocked at the transition from the double-positive to single-positive stages of development
• however, development of gamma-delta T cells is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory