Phenotypes associated with this allele

• Allele Symbol: Mst1r^tm1Sjd
• Allele Name: targeted mutation 1, Sandra J F Degen
• Allele ID: MGI:2180761
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mst1r^tm1Sjd/Mst1r^tm1Sjd	either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss)	MGI:3027716
ht2	Mst1r^tm1Sjd/Mst1r^+	either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss)	MGI:3027717

Genotype
MGI:3027716

hm1

• Allelic Composition: Mst1r^tm1Sjd/Mst1r^tm1Sjd
• Genetic Background: either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:54903 )

• 100% dead by E7.5

Genotype
MGI:3027717

ht2

• Allelic Composition: Mst1r^tm1Sjd/Mst1r⁺
• Genetic Background: either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss)

immune system

abnormal macrophage physiology ( J:54903 )

• reduced peritoneal macrophage activation, assessed by morphological changes, after stimulation with hepatocyte growth factor

increased susceptibility to bacterial infection ( J:54903 )

• more susceptible to LPS-induced death than littermate controls

hematopoietic system

abnormal macrophage physiology ( J:54903 )

• reduced peritoneal macrophage activation, assessed by morphological changes, after stimulation with hepatocyte growth factor