Phenotypes associated with this allele

• Allele Symbol: Hspa1b^tm1Clib
• Allele Name: targeted mutation 1, Claude Libert
• Allele ID: MGI:2180762
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hspa1b^tm1Clib/Hspa1b^tm1Clib	involves: 129P2/OlaHsd * C57BL/6	MGI:3851018
hm2	Hspa1b^tm1Clib/Hspa1b^tm1Clib	involves: 129P2/OlaHsd * C57BL/6J	MGI:3851016

Genotype
MGI:3851018

hm1

• Allelic Composition: Hspa1b^tm1Clib/Hspa1b^tm1Clib
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:123913 )

• unlike in wild-type mice, zinc does not prevent TNF-induced lethality

• unlike in wild-type mice, zinc does not protect against lethality induced by transplantation of B16BL6 melanoma cells

homeostasis/metabolism

decreased body temperature ( J:123913 )

• unlike in wild-type mice, heat shock does not prevent TNF-induced hypothermia

abnormal response/metabolism to endogenous compounds ( J:123913 )

• unlike in wild-type mice, zinc does not prevent TNF-induced lethality and hypothermia

Genotype
MGI:3851016

hm2

• Allelic Composition: Hspa1b^tm1Clib/Hspa1b^tm1Clib
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:76801 )

• unlike in wild-type mice, heat shock does not prevent TNF-induced lethality

homeostasis/metabolism

decreased body temperature ( J:76801 )

• unlike in wild-type mice, heat shock does not prevent TNF-induced hypothermia

abnormal nitric oxide homeostasis ( J:76801 )

• unlike in wild-type mice, heat shock does not prevent TNF-induced increased in serum nitric oxide

abnormal response/metabolism to endogenous compounds ( J:76801 )

• unlike in wild-type mice, heat shock does not prevent TNF-induced lethality, hypothermia, nitric oxide, and IL6 production

immune system

increased interleukin-6 secretion ( J:76801 )

• unlike in wild-type mice, heat shock does not prevent TNF-induced increased in serum IL6