hematopoietic system
• thymus cellularity is 2-5% of normal
|
• T cell development is blocked at the double negative CD44-CD25+ stage
|
• alphabeta T cells are absent in these mice
|
• gammadelta T cells are absent in the thymus, gut, and periphery
|
immune system
• thymus cellularity is 2-5% of normal
|
• T cell development is blocked at the double negative CD44-CD25+ stage
|
• alphabeta T cells are absent in these mice
|
• gammadelta T cells are absent in the thymus, gut, and periphery
|
endocrine/exocrine glands
• thymus cellularity is 2-5% of normal
|