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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnp2tm1Wen
targeted mutation 1, Wolfgang Engel
MGI:2180779
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnp2tm1Wen/Tnp2tm1Wen involves: 129S1/Sv * 129X1/SvJ MGI:3037939
hm2
 		Tnp2tm1Wen/Tnp2tm1Wen involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3037940
cx3
 		H1f1tm1Drab/H1f1tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129 * C57BL/6J MGI:3579100
cx4
 		H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129 * C57BL/6J MGI:3579102
cx5
 		H1f1tm1Drab/H1f1tm1Drab
Smcptm1Wen/Smcp+
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129 * C57BL/6J MGI:3579108
cx6
 		H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcp+
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129 * C57BL/6J MGI:3579109
cx7
 		H1f6tm1Drab/H1f6+
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129 * C57BL/6J MGI:3579110
cx8
 		H1f1tm1Drab/H1f1+
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129 * C57BL/6J MGI:3579111
cx9
 		H1f1tm1Drab/H1f1tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2+ 		involves: 129 * C57BL/6J MGI:3579112
cx10
 		H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2+ 		involves: 129 * C57BL/6J MGI:3579115
cx11
 		Acrtm1Wen/Acrtm1Wen
H1f1tm1Drab/H1f1tm1Drab
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129 * C57BL/6J * CD-1b MGI:3844463
cx12
 		Acrtm1Wen/Acrtm1Wen
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129/Sv * C57BL/6J * CD-1 MGI:3579099
cx13
 		Acrtm1Wen/Acrtm1Wen
H1f6tm1Ais/H1f6tm1Ais
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129/Sv * C57BL/6J * CD-1 * SJL MGI:3844461


Genotype
MGI:3037939
hm1
Allelic
Composition		 Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm head morphology ( J:76986 )
• 24% of cauda epididymis spermatozoa exhibited abnormal sperm head morphology due to acrosome malformation
• however, chromatin condensation in the sperm nucleus appeared normal
abnormal acrosome morphology ( J:76986 )
• 30% of acrosomes in epididymal sperm appeared indented and/or partially detached from the nuclear envelope
• similar abnormal acrosomes were observed in spermatids within the testis
detached acrosome ( J:76986 )
• many acrosomes were not attached to the nuclear envelope
asthenozoospermia ( J:76986 )
• reduced migration of sperm from the uterus to the oviduct was noted
male infertility ( J:76986 )
• all homozygous males were infertile
impaired sperm penetration of zona pellucida ( J:76986 )
• sperm have an impaired ability to penetrate the zona pellucida and fertilize oocytes

cellular
abnormal sperm head morphology ( J:76986 )
• 24% of cauda epididymis spermatozoa exhibited abnormal sperm head morphology due to acrosome malformation
• however, chromatin condensation in the sperm nucleus appeared normal
abnormal acrosome morphology ( J:76986 )
• 30% of acrosomes in epididymal sperm appeared indented and/or partially detached from the nuclear envelope
• similar abnormal acrosomes were observed in spermatids within the testis
detached acrosome ( J:76986 )
• many acrosomes were not attached to the nuclear envelope
asthenozoospermia ( J:76986 )
• reduced migration of sperm from the uterus to the oviduct was noted




Genotype
MGI:3037940
hm2
Allelic
Composition		 Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:76986 )
• normal male fertility was noted




Genotype
MGI:3579100
cx3
Allelic
Composition		 H1f1tm1Drab/H1f1tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f1tm1Drab mutation (0 available); any H1f1 mutation (6 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired sperm migration in female genital tract ( J:98301 )
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, amplitude, and forward movement, indicating decreased sperm motility compared to wild-type
male infertility ( J:98301 )
• produced no offspring when mated to wild-type females
impaired sperm penetration of zona pellucida ( J:98301 )
• impaired sperm penetration of zona pellucida from wild-type females

cellular
impaired sperm migration in female genital tract ( J:98301 )
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, amplitude, and forward movement, indicating decreased sperm motility compared to wild-type




Genotype
MGI:3579102
cx4
Allelic
Composition		 H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation (0 available); any H1f6 mutation (17 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract
• smaller decrease in sperm motility than seen in triple homozygous Acr/Hist1-1s/Mcsp and Acr/Hist1h1t/Mcsp mice

reproductive system
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract
• smaller decrease in sperm motility than seen in triple homozygous Acr/Hist1-1s/Mcsp and Acr/Hist1h1t/Mcsp mice
male infertility ( J:98301 )
• produced no offspring when mated to wild-type females
impaired fertilization ( J:98301 )
• only 8%-15% of wild-type oocytes were fertilized by mutant sperm (compared to 84.8% by wild-type sperm), but 71-75% of the fertilized oocytes developed into normal blastocysts (compared to 61.5% of the controls)
impaired sperm penetration of zona pellucida ( J:98301 )
• impaired sperm penetration of zona pellucida from wild-type females




Genotype
MGI:3579108
cx5
Allelic
Composition		 H1f1tm1Drab/H1f1tm1Drab
Smcptm1Wen/Smcp+
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f1tm1Drab mutation (0 available); any H1f1 mutation (6 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:98301 )
N
• male fertility is normal




Genotype
MGI:3579109
cx6
Allelic
Composition		 H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcp+
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation (0 available); any H1f6 mutation (17 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:98301 )
N
• male fertility is normal




Genotype
MGI:3579110
cx7
Allelic
Composition		 H1f6tm1Drab/H1f6+
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation (0 available); any H1f6 mutation (17 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced male fertility ( J:98301 )
• fertility of males is reduced to 20%-50% of controls




Genotype
MGI:3579111
cx8
Allelic
Composition		 H1f1tm1Drab/H1f1+
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f1tm1Drab mutation (0 available); any H1f1 mutation (6 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced male fertility ( J:98301 )
• fertility of males is reduced to 20%-50% of controls




Genotype
MGI:3579112
cx9
Allelic
Composition		 H1f1tm1Drab/H1f1tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f1tm1Drab mutation (0 available); any H1f1 mutation (6 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system




Genotype
MGI:3579115
cx10
Allelic
Composition		 H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation (0 available); any H1f6 mutation (17 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system




Genotype
MGI:3844463
cx11
Allelic
Composition		 Acrtm1Wen/Acrtm1Wen
H1f1tm1Drab/H1f1tm1Drab
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129 * C57BL/6J * CD-1b
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrtm1Wen mutation (0 available); any Acr mutation (49 available)
H1f1tm1Drab mutation (0 available); any H1f1 mutation (6 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:86670 )
• viable and fertile with normal litter sizes and normal sperm numbers, morphology and physiology




Genotype
MGI:3579099
cx12
Allelic
Composition		 Acrtm1Wen/Acrtm1Wen
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129/Sv * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrtm1Wen mutation (0 available); any Acr mutation (49 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired sperm migration in female genital tract ( J:98301 )
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, amplitude, and forward movement, indicating decreased sperm motility compared to wild-type
male infertility ( J:98301 )
• produced no offspring when mated to wild-type females
impaired binding of sperm to zona pellucida ( J:98301 )
• reduced binding of sperm to zona pellucida from wild-type females

cellular
impaired sperm migration in female genital tract ( J:98301 )
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, amplitude, and forward movement, indicating decreased sperm motility compared to wild-type




Genotype
MGI:3844461
cx13
Allelic
Composition		 Acrtm1Wen/Acrtm1Wen
H1f6tm1Ais/H1f6tm1Ais
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129/Sv * C57BL/6J * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrtm1Wen mutation (0 available); any Acr mutation (49 available)
H1f6tm1Ais mutation (0 available); any H1f6 mutation (17 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:86670 )
• viable and fertile with normal litter sizes and normal sperm numbers, morphology and physiology




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory