Phenotypes associated with this allele

• Allele Symbol: Apoa1^tm1Bres
• Allele Name: targeted mutation 1, Jan L Breslow
• Allele ID: MGI:2180783
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoa1^tm1Bres/Apoa1^tm1Bres	involves: 129S4/SvJae * C57BL/6	MGI:3783888
ht2	Apoa1^tm1Bres/Apoa1^+	involves: 129S4/SvJae * C57BL/6	MGI:3783889
cx3	Apoa1^tm1Bres/Apoa1^tm1Bres Apoa2^tm1Bres/Apoa2^tm1Bres	involves: 129S4/SvJae * C57BL/6	MGI:3783891
cx4	Apoa1^tm1Bres/Apoa1^tm1Bres Tg(Mt1-CETP)#Tall/0	involves: 129S4/SvJae * C57BL/6 * CBA/J	MGI:4941578

Genotype
MGI:3783888

hm1

• Allelic Composition: Apoa1^tm1Bres/Apoa1^tm1Bres
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased cholesterol efflux ( J:40819 )

• HDL cholesteryl ester transport is decreased 86% and 83%, respectively, when mice are fed a normal or Western-type diet compared to wild-type mice

decreased circulating cholesterol level ( J:40819 )

• mice exhibit a 72% reduced in plasma cholesterol level compared to in wild-type mice

• when fed a Western-type diet, mice exhibit a 73% reduced in plasma cholesterol level compared to in wild-type mice

• mice exhibit a 1.9-fold and 2.2-fold decrease in free cholesterol and cholesteryl ester content, respectively, compared to in wild-type mice

decreased circulating HDL cholesterol level ( J:40819 )

• mice exhibit a 74% decrease in HDL-C levels compared to wild-type mice

• when fed a Western-type diet, mice exhibit a 83% decrease in HDL-C levels compared to wild-type mice

decreased circulating LDL cholesterol level ( J:40819 )

• mice exhibit a 62% decrease in VLDL-C and LDL-C levels compared to wild-type mice

• when fed a Western-type diet, mice exhibit a 42% decrease in VLDL-C and LDL-C levels compared to wild-type mice

decreased circulating VLDL cholesterol level ( J:40819 )

• mice exhibit a 62% decrease in VLDL-C and LDL-C levels compared to wild-type mice

• when fed a Western-type diet, mice exhibit a 42% decrease in VLDL-C and LDL-C levels compared to wild-type mice

increased circulating triglyceride level ( J:40819 )

• mice exhibit an 8-fold decrease in triglycerides compared to wild-type mice

cellular

decreased cholesterol efflux ( J:40819 )

• HDL cholesteryl ester transport is decreased 86% and 83%, respectively, when mice are fed a normal or Western-type diet compared to wild-type mice

Genotype
MGI:3783889

ht2

• Allelic Composition: Apoa1^tm1Bres/Apoa1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

homeostasis/metabolism

decreased cholesterol efflux ( J:40819 )

• HDL cholesteryl ester transport is decreased when mice are fed a normal or Western-type diet compared to wild-type mice

decreased circulating HDL cholesterol level ( J:40819 )

• HDL-C levels are 78% of wild-type

cellular

decreased cholesterol efflux ( J:40819 )

• HDL cholesteryl ester transport is decreased when mice are fed a normal or Western-type diet compared to wild-type mice

Genotype
MGI:3783891

cx3

• Allelic Composition: Apoa1^tm1Bres/Apoa1^tm1Bres; Apoa2^tm1Bres/Apoa2^tm1Bres
• Genetic Background: involves: 129S4/SvJae * C57BL/6

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:40819 )

• mice exhibit a further 50% or more reduction in HDL-C levels compared to in Apoa1^tm1Bres homozygotes

Genotype
MGI:4941578

cx4

• Allelic Composition: Apoa1^tm1Bres/Apoa1^tm1Bres; Tg(Mt1-CETP)#Tall/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:40819 )

• mice exhibit a further 44% reduction in HDL-C levels compared to in Apoa1^tm1Bres homozygotes