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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd72tm1Jrp
targeted mutation 1, Jane R Parnes
MGI:2180786
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd72tm1Jrp/Cd72tm1Jrp either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) MGI:2662157
cx2
 		Cd72tm1Jrp/Cd72tm1Jrp
Tg(BCL2)22Wehi/0 		either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi) MGI:3700223


Genotype
MGI:2662157
hm1
Allelic
Composition		 Cd72tm1Jrp/Cd72tm1Jrp
Genetic
Background		 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd72tm1Jrp mutation (1 available); any Cd72 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal B cell calcium ion homeostasis ( J:76990 )
• the increase in intracellular calcium following surface IgM crosslinking is more rapid in mutant B cells than in wild-type B cells

immune system
abnormal B cell differentiation ( J:76990 )
• B cell development and maturation are delayed in young mutants
• impaired transition from pre-B to immature B cells and from immature to mature B cells
• adult mutants exhibit a slower rate of generating mature recirculating B cells
increased immature B cell number ( J:76990 )
• increase in numbers of immature IgM hi B220 lo B cells in the spleens of young mutants
increased pro-B cell number ( J:76990 )
• increase in IgM-IgD- B cells in Peyer's patches and mesenteric lymph nodes
increased B-1 B cell number ( J:76990 )
• B-1 cell numbers are increased in the spleen and peritoneal cavity
increased marginal zone B cell number ( J:76990 )
• modest increase of spleen marginal zone B cells
decreased B cell number ( J:76990 )
• splenic (B220+) B cells are decreased by 24% compared to wild-type; numbers in lymph nodes and Peyer's patches are decreased by 32% and 20%, respectively
decreased mature B cell number ( J:76990 )
• decrease in numbers of mature B cells in the bone marrow and periphery
decreased B-2 B cell number ( J:76990 )
• mature B-2 cell numbers are reduced in the periphery
decreased follicular B cell number ( J:76990 )
• 38% reduction in IgM int CD23+ mature long-lived follicular B cells in the spleen
increased pre-B cell number ( J:76990 )
• increase in the number of IgM-IgD- pre-B cells
abnormal B cell activation ( J:76990 )
• increase in the number of activated B cells
increased B cell proliferation ( J:76990 )
• splenic B cells show increased proliferative responses to low levels of IgM cross-linking and to stimulation with LPS
abnormal B cell calcium ion homeostasis ( J:76990 )
• the increase in intracellular calcium following surface IgM crosslinking is more rapid in mutant B cells than in wild-type B cells
increased IgM level ( J:76990 )
• small, but significant, increase in the serum IgM level in nonimmunized mutants
• mutants show normal T-independent responses except for a slightly stronger IgM response to TNP-Ficoll, and normal type 2 T cell-independent responses

hematopoietic system
abnormal B cell differentiation ( J:76990 )
• B cell development and maturation are delayed in young mutants
• impaired transition from pre-B to immature B cells and from immature to mature B cells
• adult mutants exhibit a slower rate of generating mature recirculating B cells
increased immature B cell number ( J:76990 )
• increase in numbers of immature IgM hi B220 lo B cells in the spleens of young mutants
increased pro-B cell number ( J:76990 )
• increase in IgM-IgD- B cells in Peyer's patches and mesenteric lymph nodes
increased B-1 B cell number ( J:76990 )
• B-1 cell numbers are increased in the spleen and peritoneal cavity
increased marginal zone B cell number ( J:76990 )
• modest increase of spleen marginal zone B cells
decreased B cell number ( J:76990 )
• splenic (B220+) B cells are decreased by 24% compared to wild-type; numbers in lymph nodes and Peyer's patches are decreased by 32% and 20%, respectively
decreased mature B cell number ( J:76990 )
• decrease in numbers of mature B cells in the bone marrow and periphery
decreased B-2 B cell number ( J:76990 )
• mature B-2 cell numbers are reduced in the periphery
decreased follicular B cell number ( J:76990 )
• 38% reduction in IgM int CD23+ mature long-lived follicular B cells in the spleen
increased pre-B cell number ( J:76990 )
• increase in the number of IgM-IgD- pre-B cells
abnormal B cell activation ( J:76990 )
• increase in the number of activated B cells
increased B cell proliferation ( J:76990 )
• splenic B cells show increased proliferative responses to low levels of IgM cross-linking and to stimulation with LPS
abnormal B cell calcium ion homeostasis ( J:76990 )
• the increase in intracellular calcium following surface IgM crosslinking is more rapid in mutant B cells than in wild-type B cells
increased IgM level ( J:76990 )
• small, but significant, increase in the serum IgM level in nonimmunized mutants
• mutants show normal T-independent responses except for a slightly stronger IgM response to TNP-Ficoll, and normal type 2 T cell-independent responses

cellular
increased B cell proliferation ( J:76990 )
• splenic B cells show increased proliferative responses to low levels of IgM cross-linking and to stimulation with LPS




Genotype
MGI:3700223
cx2
Allelic
Composition		 Cd72tm1Jrp/Cd72tm1Jrp
Tg(BCL2)22Wehi/0
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd72tm1Jrp mutation (1 available); any Cd72 mutation (30 available)
Tg(BCL2)22Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased immature B cell number ( J:76990 )
• increase in the frequency of immature B cells in the spleen and bone marrow
decreased mature B cell number ( J:76990 )
• reduction in the frequency of mature B cells in the spleen and bone marrow
abnormal B cell physiology ( J:76990 )
• mice show only partial correction of B cell maturation defect and have reduced numbers of mature B cells

hematopoietic system
increased immature B cell number ( J:76990 )
• increase in the frequency of immature B cells in the spleen and bone marrow
decreased mature B cell number ( J:76990 )
• reduction in the frequency of mature B cells in the spleen and bone marrow
abnormal B cell physiology ( J:76990 )
• mice show only partial correction of B cell maturation defect and have reduced numbers of mature B cells




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11/12/2024
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