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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd72tm1Jrp
targeted mutation 1, Jane R Parnes
MGI:2180786
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd72tm1Jrp/Cd72tm1Jrp either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) MGI:2662157
cx2
Cd72tm1Jrp/Cd72tm1Jrp
Tg(BCL2)22Wehi/0
either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi) MGI:3700223


Genotype
MGI:2662157
hm1
Allelic
Composition
Cd72tm1Jrp/Cd72tm1Jrp
Genetic
Background
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd72tm1Jrp mutation (1 available); any Cd72 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• the increase in intracellular calcium following surface IgM crosslinking is more rapid in mutant B cells than in wild-type B cells

immune system
• B cell development and maturation are delayed in young mutants
• impaired transition from pre-B to immature B cells and from immature to mature B cells
• adult mutants exhibit a slower rate of generating mature recirculating B cells
• increase in numbers of immature IgM hi B220 lo B cells in the spleens of young mutants
• increase in IgM-IgD- B cells in Peyer's patches and mesenteric lymph nodes
• B-1 cell numbers are increased in the spleen and peritoneal cavity
• modest increase of spleen marginal zone B cells
• splenic (B220+) B cells are decreased by 24% compared to wild-type; numbers in lymph nodes and Peyer's patches are decreased by 32% and 20%, respectively
• decrease in numbers of mature B cells in the bone marrow and periphery
• mature B-2 cell numbers are reduced in the periphery
• 38% reduction in IgM int CD23+ mature long-lived follicular B cells in the spleen
• increase in the number of IgM-IgD- pre-B cells
• increase in the number of activated B cells
• splenic B cells show increased proliferative responses to low levels of IgM cross-linking and to stimulation with LPS
• the increase in intracellular calcium following surface IgM crosslinking is more rapid in mutant B cells than in wild-type B cells
• small, but significant, increase in the serum IgM level in nonimmunized mutants
• mutants show normal T-independent responses except for a slightly stronger IgM response to TNP-Ficoll, and normal type 2 T cell-independent responses

hematopoietic system
• B cell development and maturation are delayed in young mutants
• impaired transition from pre-B to immature B cells and from immature to mature B cells
• adult mutants exhibit a slower rate of generating mature recirculating B cells
• increase in numbers of immature IgM hi B220 lo B cells in the spleens of young mutants
• increase in IgM-IgD- B cells in Peyer's patches and mesenteric lymph nodes
• B-1 cell numbers are increased in the spleen and peritoneal cavity
• modest increase of spleen marginal zone B cells
• splenic (B220+) B cells are decreased by 24% compared to wild-type; numbers in lymph nodes and Peyer's patches are decreased by 32% and 20%, respectively
• decrease in numbers of mature B cells in the bone marrow and periphery
• mature B-2 cell numbers are reduced in the periphery
• 38% reduction in IgM int CD23+ mature long-lived follicular B cells in the spleen
• increase in the number of IgM-IgD- pre-B cells
• increase in the number of activated B cells
• splenic B cells show increased proliferative responses to low levels of IgM cross-linking and to stimulation with LPS
• the increase in intracellular calcium following surface IgM crosslinking is more rapid in mutant B cells than in wild-type B cells
• small, but significant, increase in the serum IgM level in nonimmunized mutants
• mutants show normal T-independent responses except for a slightly stronger IgM response to TNP-Ficoll, and normal type 2 T cell-independent responses

cellular
• splenic B cells show increased proliferative responses to low levels of IgM cross-linking and to stimulation with LPS




Genotype
MGI:3700223
cx2
Allelic
Composition
Cd72tm1Jrp/Cd72tm1Jrp
Tg(BCL2)22Wehi/0
Genetic
Background
either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd72tm1Jrp mutation (1 available); any Cd72 mutation (30 available)
Tg(BCL2)22Wehi mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increase in the frequency of immature B cells in the spleen and bone marrow
• reduction in the frequency of mature B cells in the spleen and bone marrow
• mice show only partial correction of B cell maturation defect and have reduced numbers of mature B cells

hematopoietic system
• increase in the frequency of immature B cells in the spleen and bone marrow
• reduction in the frequency of mature B cells in the spleen and bone marrow
• mice show only partial correction of B cell maturation defect and have reduced numbers of mature B cells





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory