Phenotypes associated with this allele

• Allele Symbol: Cd81^tm1Lvy
• Allele Name: targeted mutation 1, Shoshana Levy
• Allele ID: MGI:2180805
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd81^tm1Lvy/Cd81^tm1Lvy	B6ByJ.129-Cd81^tm1Lvy	MGI:4358178
hm2	Cd81^tm1Lvy/Cd81^tm1Lvy	CByJ.129-Cd81^tm1Lvy	MGI:4358133
hm3	Cd81^tm1Lvy/Cd81^tm1Lvy	either: (B6ByJ.129-Cd81^tm1Lvy x CByJ.129-Cd81^tm1Lvy)F1 or (CByJ.129-Cd81^tm1Lvy x B6ByJ.129-Cd81^tm1Lvy)F1	MGI:4358179
hm4	Cd81^tm1Lvy/Cd81^tm1Lvy	involves: 129S1/Sv * 129X1/SvJ	MGI:4358124
hm5	Cd81^tm1Lvy/Cd81^tm1Lvy	involves: 129S1/Sv * 129X1/SvJ * NIHS-BC	MGI:4358176

Genotype
MGI:4358178

hm1

• Allelic Composition: Cd81^tm1Lvy/Cd81^tm1Lvy
• Genetic Background: B6ByJ.129-Cd81^tm1Lvy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:79426 )

N • Background Sensitivity: the enlarged brain mass observed in Cd81^tm1Lvy homozygotes on BALB/c and mixed backgrounds is not observed on this background

Genotype
MGI:4358133

hm2

• Allelic Composition: Cd81^tm1Lvy/Cd81^tm1Lvy
• Genetic Background: CByJ.129-Cd81^tm1Lvy

immune system

abnormal T-helper 2 physiology ( J:46171 )

• peribronchial lymph node lymphocytes from OVA challenged mice produce much less IFN-gamma, IL-4, IL-5 and IL-13 upon restimulation

• splenocytes from OVA-challenged mice produce half the IFN-gamma, IL-4 and IL-13 as controls

• T cells can be differentiated into Th2 effector cells in vitro

decreased susceptibility to type I hypersensitivity reaction ( J:46171 )

• sensitized mice have decreased airway hyperresponsiveness to ova antigen after previously exposure

• mice have much reduced peribronchiolar and perivascular inflammatory infiltrates after OVA challenge with no sign of hypertrophy or mucin

• B cells numbers in peribronchiolar lymph nodes of OVA challenged mice are reduced by about half

nervous system

increased brain weight ( J:79426 )

• Background Sensitivity: there is a modest increase in brain weight compared to littermate controls on while no effect is seen by the null mutation on a C57BL/6 background

increased hippocampus volume ( J:79426 )

• Background Sensitivity: hippocampus volume is slightly larger unlike on C57BL/6 background where no significant effect is seen

thickened cerebral cortex ( J:79426 )

• Background Sensitivity: the cerebral cortex is thicker than controls on a mixed background which contributes to the increased brain weight of this strain of mice

hematopoietic system

abnormal T-helper 2 physiology ( J:46171 )

• peribronchial lymph node lymphocytes from OVA challenged mice produce much less IFN-gamma, IL-4, IL-5 and IL-13 upon restimulation

• splenocytes from OVA-challenged mice produce half the IFN-gamma, IL-4 and IL-13 as controls

• T cells can be differentiated into Th2 effector cells in vitro

Genotype
MGI:4358179

hm3

• Allelic Composition: Cd81^tm1Lvy/Cd81^tm1Lvy
• Genetic Background: either: (B6ByJ.129-Cd81^tm1Lvy x CByJ.129-Cd81^tm1Lvy)F1 or (CByJ.129-Cd81^tm1Lvy x B6ByJ.129-Cd81^tm1Lvy)F1

nervous system

increased brain weight ( J:79426 )

• Background Sensitivity: brains are about 20% heavier than littermate controls on this F1 background while no effect is seen by the null mutation on a C57BL/6 background

• Background Sensitivity: the mean brain weight is 570 mg, which is three standard deviations higher than that of typical mice

abnormal corpus callosum morphology ( J:79426 )

• despite increased brain size, corpus callosum cross sectional area is comparable to controls

abnormal hippocampus morphology ( J:79426 )

abnormal hippocampus CA1 region morphology ( J:79426 )

• mice have a 7.5% increase in the thickness of CA1 relative to the normal littermates

increased hippocampus volume ( J:79426 )

• Background Sensitivity: hippocampus volume is significantly larger unlike on C57BL/6 background where no significant effect is seen

thickened cerebral cortex ( J:79426 )

• Background Sensitivity: the cerebral cortex is thicker than controls on a F1 background which contributes to the increased brain weight of this strain of mice

abnormal CNS glial cell morphology ( J:79426 )

• the glial cell to neuronal cell ratio is significantly increased in the neocortex

• neuronal cell density is decreased while glial cell density is normal indicating increased number of glial cells

abnormal microglial cell morphology ( J:79426 )

• numbers of microglial cells in the hippocampus are increased by 58%

increased astrocyte number ( J:79426 )

• there is a significant increase in the number of astrocytes within the hippocampus relative to their control littermates

• astrocyte cell size is not enlarged

abnormal neuron morphology ( J:79426 )

• neuronal cell density is decreased due to increased glial cell number

abnormal hippocampus pyramidal cell morphology ( J:79426 )

• there is a greater expanse of the pyramidal cells' dendritic fields

immune system

abnormal microglial cell morphology ( J:79426 )

• numbers of microglial cells in the hippocampus are increased by 58%

hematopoietic system

abnormal microglial cell morphology ( J:79426 )

• numbers of microglial cells in the hippocampus are increased by 58%

Genotype
MGI:4358124

hm4

• Allelic Composition: Cd81^tm1Lvy/Cd81^tm1Lvy
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

immune system

abnormal B cell morphology ( J:40394 )

• B cells have reduced expression of CD19

decreased IgG level ( J:40394 )

• total IgG levels are reduced 4 and 8 weeks after mice are immunized with ovalbumin

decreased IgG1 level ( J:40394 )

• IgG1 levels are reduced 4 and 8 weeks after mice are immunized with ovalbumin

abnormal T-helper 2 physiology ( J:40394 )

• mice have less Th2-mediated immunoglobin response to ovalbumin, a Th2 antigen

decreased susceptibility to parasitic infection ( J:126000 )

• mice are resistant to Plasmodium yoelii and P.falciparum infection when administered sporozoites IV

• mice are not resistant to infection with intraperitoneal inoculation of P. yoelii-infected erythrocytes

• the exoerythrocytic form of the parasite is not detected in the liver after sporozoite infection as occurs in controls

• parasites fail to form intracellular vacuoles in hepatocytes as occurs in infected wild-type hepatocytes

• mice are not resistant to P. Berghei infection which use a CD81-independent mechanism to form vacuoles in hepatocytes

hematopoietic system

abnormal B cell morphology ( J:40394 )

• B cells have reduced expression of CD19

decreased IgG level ( J:40394 )

• total IgG levels are reduced 4 and 8 weeks after mice are immunized with ovalbumin

decreased IgG1 level ( J:40394 )

• IgG1 levels are reduced 4 and 8 weeks after mice are immunized with ovalbumin

abnormal T-helper 2 physiology ( J:40394 )

• mice have less Th2-mediated immunoglobin response to ovalbumin, a Th2 antigen

Genotype
MGI:4358176

hm5

• Allelic Composition: Cd81^tm1Lvy/Cd81^tm1Lvy
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NIHS-BC

nervous system

increased brain weight ( J:79426 )

• Background Sensitivity: brains are about 20% heavier than littermate controls on a mixed background while no effect is seen by the null mutation on a C57BL/6 background

• Background Sensitivity: the mean brain weight is 570 mg-three standard deviations higher than that of typical mice

abnormal hippocampus morphology ( J:79426 )

• hippocampus are enlarged with increased numbers of astrocytes

abnormal hippocampus CA1 region morphology ( J:79426 )

• mice have a 7.5% increase in the thickness of CA1 relative to the normal littermates

increased hippocampus volume ( J:79426 )

• Background Sensitivity: hippocampus volume is significantly larger unlike on C57BL/6 background where no significant effect is seen

thickened cerebral cortex ( J:79426 )

• Background Sensitivity: the cerebral cortex is thicker than controls on a mixed background which contributes to the increased brain weight of this strain of mice

abnormal CNS glial cell morphology ( J:79426 )

• the glial cell to neuronal cell ratio is significantly increased in the neocortex

• neuronal cell density is decreased while glial cell density is normal indicating increased number of glial cells

increased astrocyte number ( J:79426 )

• there is a significant increase in the number of astrocytes within the hippocampus relative to their control littermates

abnormal neuron morphology ( J:79426 )

• neuronal cell density is decreased due to increased glial cell number

abnormal hippocampus pyramidal cell morphology ( J:79426 )

• there is a greater expanse of the pyramidal cells' dendritic fields