mortality/aging
• only 11% of animals survive past 60 hours after birth
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immune system
• natural killer cells from newborns exhibit impaired IFN-gamma production when stimulated with IL-12 plus IL-18
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• IL-15 induced natural killer cells generated from mutant spleens show impaired cytotoxic activity against YAC-1 cells
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respiratory system
• at 24 hours after birth, mutants exhibit emphysematous changes in the lungs
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hematopoietic system
• natural killer cells from newborns exhibit impaired IFN-gamma production when stimulated with IL-12 plus IL-18
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• IL-15 induced natural killer cells generated from mutant spleens show impaired cytotoxic activity against YAC-1 cells
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