Phenotypes associated with this allele

• Allele Symbol: Fgf2^tm1Bee
• Allele Name: targeted mutation 1, Friedrich Beerman
• Allele ID: MGI:2180834
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf2^tm1Bee/Fgf2^tm1Bee	B6.129P2-Fgf2^tm1Bee	MGI:3763730
cx2	Fgf2^tm1Bee/Fgf2^tm1Bee Tg(Tyrp1-TAg)3434Bee/?	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:3763732
cx3	Fgf2^tm1Bee/Fgf2^+ Tg(Tyrp1-TAg)3434Bee/?	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:3763733

Genotype
MGI:3763730

hm1

• Allelic Composition: Fgf2^tm1Bee/Fgf2^tm1Bee
• Genetic Background: B6.129P2-Fgf2^tm1Bee

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:75629 )

N • mice have normal retina morphology and both the retinal pigmented epithelium and the choroids are pigmented

Genotype
MGI:3763732

cx2

• Allelic Composition: Fgf2^tm1Bee/Fgf2^tm1Bee; Tg(Tyrp1-TAg)3434Bee/?
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

vision/eye

increased eye tumor incidence ( J:75629 )

• eye tumors develop at 2 to 3 months of age with pigmented cells observed in the inguinal lymph nodes and, in some mice, the spleen

• in 1-day old mice, tumors are present in the anterior part of the retinal pigmented epithelium and the optic nerve

• in 14-day old mice, tumors are advanced further and the posterior eye cavity is filled with tumor cells

• tumor cells are poorly pigmented or nonpigmented

• however, islet of pigmented cells can be observed in the optic nerve

mortality/aging

decreased tumor-free survival time ( J:75629 )

• mice die at 11.7 weeks of age likely due to proliferation of tumor cells in the brain and near the optic chiasm

neoplasm

increased eye tumor incidence ( J:75629 )

• eye tumors develop at 2 to 3 months of age with pigmented cells observed in the inguinal lymph nodes and, in some mice, the spleen

• in 1-day old mice, tumors are present in the anterior part of the retinal pigmented epithelium and the optic nerve

• in 14-day old mice, tumors are advanced further and the posterior eye cavity is filled with tumor cells

• tumor cells are poorly pigmented or nonpigmented

• however, islet of pigmented cells can be observed in the optic nerve

Genotype
MGI:3763733

cx3

• Allelic Composition: Fgf2^tm1Bee/Fgf2⁺; Tg(Tyrp1-TAg)3434Bee/?
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

mortality/aging

decreased tumor-free survival time ( J:75629 )

• mice die at 11.5 weeks of age likely due to proliferation of tumor cells in the brain and near the optic chiasm