Phenotypes associated with this allele

• Allele Symbol: Itga4^tm1Jty
• Allele Name: targeted mutation 1, Joy T Yang
• Allele ID: MGI:2180843
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itga4^tm1Jty/Itga4^tm1Jty	involves: 129S6/SvEvTac * C57BL/6N	MGI:3620633
ht2	Itga4^tm1Hyn/Itga4^tm1Jty	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N	MGI:3620634

Genotype
MGI:3620633

hm1

• Allelic Composition: Itga4^tm1Jty/Itga4^tm1Jty
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:76747 )

• about 50% die at around E11 with failure of allantois-chorion fusion

• about 50% die around E12 with cardiac defects

embryo

failure of chorioallantoic fusion ( J:76747 )

• about 50% exhibit failure of allantois-chorion fusion

cardiovascular system

abnormal epicardium development ( J:76747 )

• migration of epicardial progenitor cells is impaired due to inefficient budding of proepicardial cysts and a failure of the cells in the cysts to migrate on the heart

• proepicardial cysts have larger villi protrusions with budding cysts and the villi did not have the vesicle-like morphology seen in wild-type

absent epicardium ( J:76747 )

• epicardium fails to form

heart hemorrhage ( J:76747 )

• cardiac hemorrhage

Genotype
MGI:3620634

ht2

• Allelic Composition: Itga4^tm1Hyn/Itga4^tm1Jty
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

cardiovascular system

absent epicardium ( J:76747 )

• epicardium fails to form