mortality/aging
• mutant embryos die between E3.5 and E8.5, however the exact stage of death is not defined
|
cellular
• embryos exhibit irregular sized nuclei and micronuclei
|
• mitotic chromosomes display a scattered and often highly condensed configuration and do not segregate in an ordered fashion
|
• mitotic disarray, with abnormal progression from metaphase to anaphase during the morula stage
|
embryo
• 80% of E3.5 embryos are delayed in their development or less healthy
|
growth/size/body
• 80% of E3.5 embryos are delayed in their development or less healthy
|