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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cenpc1tm1Khac
targeted mutation 1, K H Andy Choo
MGI:2180846
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cenpc1tm1Khac/Cenpc1tm1Khac involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2662549


Genotype
MGI:2662549
hm1
Allelic
Composition
Cenpc1tm1Khac/Cenpc1tm1Khac
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cenpc1tm1Khac mutation (0 available); any Cenpc1 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutant embryos die between E3.5 and E8.5, however the exact stage of death is not defined

cellular
• embryos exhibit irregular sized nuclei and micronuclei
• mitotic chromosomes display a scattered and often highly condensed configuration and do not segregate in an ordered fashion
• mitotic disarray, with abnormal progression from metaphase to anaphase during the morula stage

embryo
• 80% of E3.5 embryos are delayed in their development or less healthy

growth/size/body
• 80% of E3.5 embryos are delayed in their development or less healthy





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory