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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Socs3tm1Wsa
targeted mutation 1, Warren S Alexander
MGI:2180861
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Socs3tm1Wsa/Socs3tm1Wsa either: C57BL/6-Socs3tm1Wsa or (involves: 129 * C57BL/6) MGI:4430250
ht2
 		Socs3tm1Wsa/Socs3tm2.1Wsa involves: C57BL/6 MGI:4430248
cn3
 		Socs3tm1Wsa/Socs3tm2Wsa
Lyz2tm1(cre)Ifo/? 		involves: 129P2/OlaHsd * C57BL/6 MGI:4430241
cn4
 		Socs3tm1Wsa/Socs3tm2Wsa
Tg(Vav1-cre)1Awr/0 		involves: C57BL/6 MGI:3043869
cn5
 		Socs3tm1Wsa/Socs3tm2Wsa
Tg(Alb1-cre)1Dlr/0 		involves: C57BL/6 * FVB/N MGI:4430246


Genotype
MGI:4430250
hm1
Allelic
Composition		 Socs3tm1Wsa/Socs3tm1Wsa
Genetic
Background		 either: C57BL/6-Socs3tm1Wsa or (involves: 129 * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm1Wsa mutation (0 available); any Socs3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
decreased embryo size ( J:70667 )
• slightly smaller size from E10.5 on

embryo
abnormal placenta vasculature ( J:70667 )
• the network of embryonic vessels and maternal sinuses in the placenta are poorly developed
• by E12.5, dilation of maternal and embryonic vessels and pooling of maternal blood in the labyrinthine layer of the placenta are observed
abnormal placental labyrinth vasculature morphology ( J:70667 )
• decrease in vascularity of the labyrinth
decreased embryo size ( J:70667 )
• slightly smaller size from E10.5 on
increased trophoblast giant cell number ( J:70667 )
• increase in the number of giant trophoblast cells at E9.5
decreased spongiotrophoblast cell number ( J:70667 )
• spongiotrophoblast cells are reduced
decreased spongiotrophoblast size ( J:70667 )
• decrease in spongiotrophoblast layer at E9.5
abnormal placenta labyrinth morphology ( J:70667 )
• the labyrinthine trophoblast layer is thickened but the labyrinth is thinner
abnormal placenta development ( J:70667 )
• delay in chorioallantoic branching

liver/biliary system
small liver ( J:70667 )
• livers appear small at E12.5
liver hypoplasia ( J:70667 )
• total cellularity of liver is reduced 10-fold at E12.5
• however, embryonic hematopoiesis appears normal

cardiovascular system
abnormal placenta vasculature ( J:70667 )
• the network of embryonic vessels and maternal sinuses in the placenta are poorly developed
• by E12.5, dilation of maternal and embryonic vessels and pooling of maternal blood in the labyrinthine layer of the placenta are observed
abnormal placental labyrinth vasculature morphology ( J:70667 )
• decrease in vascularity of the labyrinth




Genotype
MGI:4430248
ht2
Allelic
Composition		 Socs3tm1Wsa/Socs3tm2.1Wsa
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm1Wsa mutation (0 available); any Socs3 mutation (22 available)
Socs3tm2.1Wsa mutation (0 available); any Socs3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:83645 )
• die at E13.5 due to placental insufficiency

embryo
increased trophoblast giant cell number ( J:83645 )
• placenta at E12.5 shows expansion of trophoblast giant cells
absent spongiotrophoblast ( J:83645 )
• spongiotrophoblast is absent at E12.5




Genotype
MGI:4430241
cn3
Allelic
Composition		 Socs3tm1Wsa/Socs3tm2Wsa
Lyz2tm1(cre)Ifo/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Socs3tm1Wsa mutation (0 available); any Socs3 mutation (22 available)
Socs3tm2Wsa mutation (3 available); any Socs3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:83645 )
• macrophages stimulated with macrophage colony-stimulating factor (M-CSF) in the presence of IL-6, but not IFN-gamma, show an increase in the inhibition of proliferation compared to controls, indicating that cells are hyperresponsive to IL-6 but not IFN-gamma

hematopoietic system
abnormal macrophage physiology ( J:83645 )
• macrophages stimulated with macrophage colony-stimulating factor (M-CSF) in the presence of IL-6, but not IFN-gamma, show an increase in the inhibition of proliferation compared to controls, indicating that cells are hyperresponsive to IL-6 but not IFN-gamma




Genotype
MGI:3043869
cn4
Allelic
Composition		 Socs3tm1Wsa/Socs3tm2Wsa
Tg(Vav1-cre)1Awr/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm1Wsa mutation (0 available); any Socs3 mutation (22 available)
Socs3tm2Wsa mutation (3 available); any Socs3 mutation (22 available)
Tg(Vav1-cre)1Awr mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged spleen ( J:89785 )
• splenomegaly in aged mice which is further enhanced by G-CSF injection
abnormal definitive hematopoiesis ( J:89785 )
• hematopoiesis is perturbed after 17 weeks of age
abnormal erythropoiesis ( J:89785 )
• erythropoiesis is diminished in the bone marrow but increases in the spleen
abnormal myelopoiesis ( J:89785 )
• increased myelopoiesis in the bone marrow
• cells from the neutrophilic granulocyte lineage, when stimulated with G-CSF, show an increase in cloning frequency, survival, and proliferative capacity
• myeloid cells are hyperresponsive to G-CSF and exhibit increased proliferation and survival upon stimulation
abnormal granulocyte differentiation ( J:89785 )
• abnormalities in G-CSF-induced emergency granulocyte production; mutants injected with G-CSG exhibit enhanced neutrophilia, progenitor cell mobilization, and splenomegaly, and develop inflammatory neutrophil infiltration into multiple tissues and hind-leg paresis
extramedullary hematopoiesis ( J:89785 )
• splenomegaly with prominent extramedullary hematopoiesis
• splenomegaly is enhanced by injection with G-CSF
increased neutrophil cell number ( J:89785 )
• mutants develop neutrophilia in adulthood
• neutrophilia is enhanced by injection with granulocyte colony-stimulating factor (G-CSF)
abnormal hematopoietic stem cell morphology ( J:89785 )
• hematopoietic progenitors show enhanced G-CSF and IL-6 induced colony formation
• G-CSF responsive progenitor cells generate higher proportions of macrophage and granulocyte-macrophage colonies than control cells

immune system
enlarged spleen ( J:89785 )
• splenomegaly in aged mice which is further enhanced by G-CSF injection
abnormal myelopoiesis ( J:89785 )
• increased myelopoiesis in the bone marrow
• cells from the neutrophilic granulocyte lineage, when stimulated with G-CSF, show an increase in cloning frequency, survival, and proliferative capacity
• myeloid cells are hyperresponsive to G-CSF and exhibit increased proliferation and survival upon stimulation
abnormal granulocyte differentiation ( J:89785 )
• abnormalities in G-CSF-induced emergency granulocyte production; mutants injected with G-CSG exhibit enhanced neutrophilia, progenitor cell mobilization, and splenomegaly, and develop inflammatory neutrophil infiltration into multiple tissues and hind-leg paresis
increased neutrophil cell number ( J:89785 )
• mutants develop neutrophilia in adulthood
• neutrophilia is enhanced by injection with granulocyte colony-stimulating factor (G-CSF)
increased inflammatory response ( J:89785 )
• mutants develop an inflammatory disease after 17 weeks of age characterized by inflammation in the pleural and peritoneal cavities, neutrophil leukocytosis, and infiltration of liver and lungs by hematopoietic cells from multiple lineages
liver inflammation ( J:89785 )
• infiltration of liver by hematopoietic cells from multiple lineages
lung inflammation ( J:89785 )
• infiltration of the lungs by hematopoietic cells from multiple lineages

digestive/alimentary system

liver/biliary system
liver inflammation ( J:89785 )
• infiltration of liver by hematopoietic cells from multiple lineages

respiratory system
lung inflammation ( J:89785 )
• infiltration of the lungs by hematopoietic cells from multiple lineages

cellular
abnormal granulocyte differentiation ( J:89785 )
• abnormalities in G-CSF-induced emergency granulocyte production; mutants injected with G-CSG exhibit enhanced neutrophilia, progenitor cell mobilization, and splenomegaly, and develop inflammatory neutrophil infiltration into multiple tissues and hind-leg paresis

growth/size/body
enlarged spleen ( J:89785 )
• splenomegaly in aged mice which is further enhanced by G-CSF injection




Genotype
MGI:4430246
cn5
Allelic
Composition		 Socs3tm1Wsa/Socs3tm2Wsa
Tg(Alb1-cre)1Dlr/0
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm1Wsa mutation (0 available); any Socs3 mutation (22 available)
Socs3tm2Wsa mutation (3 available); any Socs3 mutation (22 available)
Tg(Alb1-cre)1Dlr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:83645 )
• mice develop normally, are healthy and fertile, and liver function appears normal




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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory