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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Seletm1Roml
targeted mutation 1, Mark A Labow
MGI:2180868
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Seletm1Roml/Seletm1Roml involves: 129S1/Sv MGI:3699810
hm2
 		Seletm1Roml/Seletm1Roml involves: 129S1/Sv * C57BL/6 MGI:3699809
hm3
 		Seletm1Roml/Seletm1Roml involves: 129S1/Sv * C57BL/6J MGI:3699814


Genotype
MGI:3699810
hm1
Allelic
Composition		 Seletm1Roml/Seletm1Roml
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm1Roml mutation (0 available); any Sele mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:113536 )
• Background Sensitivity: T lymphocyte migration and accumulation into dermal inflammatory regions induced by ConA is inhibited by 50%, however IFN-gamma, IFN-gamma plus TNF-alpha, or TNF-alpha infiltration is unaffected; on the 129S1/Sv background, sensitivity to various lymphocyte stimulators is different than on C57BL/6 background

hematopoietic system
abnormal T cell physiology ( J:113536 )
• Background Sensitivity: T lymphocyte migration and accumulation into dermal inflammatory regions induced by ConA is inhibited by 50%, however IFN-gamma, IFN-gamma plus TNF-alpha, or TNF-alpha infiltration is unaffected; on the 129S1/Sv background, sensitivity to various lymphocyte stimulators is different than on C57BL/6 background




Genotype
MGI:3699809
hm2
Allelic
Composition		 Seletm1Roml/Seletm1Roml
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm1Roml mutation (0 available); any Sele mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:113536 )
• Background Sensitivity: T lymphocyte migration and accumulation into dermal inflammatory regions induced by IFN-gamma, IFN-gamma plus TNF-alpha, and ConA is inhibited by 45-65%, however TNF-alpha induced infiltration is unaffected; on the C57BL/6 background, sensitivity to various lymphocyte stimulators is different than on a 129S/Sv background

hematopoietic system
abnormal T cell physiology ( J:113536 )
• Background Sensitivity: T lymphocyte migration and accumulation into dermal inflammatory regions induced by IFN-gamma, IFN-gamma plus TNF-alpha, and ConA is inhibited by 45-65%, however TNF-alpha induced infiltration is unaffected; on the C57BL/6 background, sensitivity to various lymphocyte stimulators is different than on a 129S/Sv background




Genotype
MGI:3699814
hm3
Allelic
Composition		 Seletm1Roml/Seletm1Roml
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm1Roml mutation (0 available); any Sele mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:22062 , J:28110 )
• homozygotes are viable, fertile, normal sized, exhibit no obvious developmental alterations and no changes in the recruitment of neutrophils in several models of inflammation (J:22062)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory