Analysis Tools|
Allele Symbol Allele Name Allele ID |
Prkacbtm1Gsm targeted mutation 1, G Stanley McKnight MGI:2180946 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants are unable to maintain a potentiated response upon high-frequency stimulation, resulting in a late phase of long-term potentiation that is only 30% of controls, however paired-pulse facilitation is unaffected
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• low-frequency stimulation fails to produce lasting synaptic depression as it does in wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Neural tube defects leading to spina bifida in Prkacatm1Gsm/Prkaca+ Prkacbtm1Gsm/Prkacbtm1Gsm and Prkacatm1Gsm/Prkacatm1Gsm Prkacbtm1Gsm/Prkacb+ mice
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• if mutant pups are kept with their parents, they are rejected and left out of the litter and die, probably from starvation
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• increase in apoptotic cells in the dorsal and lateral regions of the neural tube
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• 100% show spinal neural tube defects
• E9.5-10.5 embryos exhibit a closed neural tube with an expanded alar plate and enlarged lumen in the thoracic and lumbar regions and an expanded neuroepithelium
• E10.5 or older embryos show a drastic increase in the expansion of the neural canal (enlarged lumen) and a neuroepithelium with a higher cell density
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• E9.5-E10.5 embryos exhibit an expanded neuroepithelium with a higher cell density
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• at the thoracic and lumbar regions
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• altered neuronal identity in the neural tube posterior to the forelimb buds leading to a ventralized neural tube (appearance of ventral neuronal progenitors in the dorsal neural tube and loss of dorsal cell types)
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• dorsal root ganglia form in E10.5 embryos but regress at E12.5
• significant increase in cell death in the dorsal root ganglia adjacent to the affected neural tube
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• dorsal root ganglia are formed in E10.5 embryos but are disorganized
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• spinal column defects are located in the thoracic and lumbar regions
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• ventral curvature of the spine at the defective region
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• vertebral arches fail to fuse at the dorsal midline between forelimbs and hindlimbs
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• 100% show spinal neural tube defects
• E9.5-10.5 embryos exhibit a closed neural tube with an expanded alar plate and enlarged lumen in the thoracic and lumbar regions and an expanded neuroepithelium
• E10.5 or older embryos show a drastic increase in the expansion of the neural canal (enlarged lumen) and a neuroepithelium with a higher cell density
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• E9.5-E10.5 embryos exhibit an expanded neuroepithelium with a higher cell density
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• at the thoracic and lumbar regions
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• increase in apoptotic cells in the dorsal and lateral regions of the neural tube
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Neural tube defects leading to spina bifida in Prkacatm1Gsm/Prkaca+ Prkacbtm1Gsm/Prkacbtm1Gsm and Prkacatm1Gsm/Prkacatm1Gsm Prkacbtm1Gsm/Prkacb+ mice
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• die by E14
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• 75% show spinal neural tube defects
• 25% show spinal neural tube defects and exencephaly
• E9.5-10.5 embryos exhibit a closed neural tube with an expanded alar plate and enlarged lumen in the thoracic and lumbar regions and an expanded neuroepithelium
• E10.5 or older embryos show a drastic increase in the expansion of the neural canal (enlarged lumen) and a neuroepithelium with a higher cell density
• exhibit an increase in apoptotic cells in the dorsal and lateral regions of the neural tube
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• E9.5-E10.5 embryos exhibit an expanded neuroepithelium with a higher cell density
|
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• at the thoracic and lumbar regions
|
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• 25% show spinal neural tube defects and exencephaly; exencephaly alone is not observed
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• altered neuronal identity in the neural tube posterior to the forelimb buds leading to a ventralized neural tube (appearance of ventral neuronal progenitors in the dorsal neural tube and loss of dorsal cell types)
|
|
• dorsal root ganglia form in E10.5 embryos but regress at E12.5
• significant increase in cell death in the dorsal root ganglia adjacent to the affected neural tube
|
|
• dorsal root ganglia are formed in E10.5 embryos but are disorganized
|
|
• spinal column defects are located in the thoracic and lumbar regions
|
|
• ventral curvature of the spine at the defective region
|
|
• vertebral arches fail to fuse at the dorsal midline between forelimbs and hindlimbs
|
|
• 75% show spinal neural tube defects
• 25% show spinal neural tube defects and exencephaly
• E9.5-10.5 embryos exhibit a closed neural tube with an expanded alar plate and enlarged lumen in the thoracic and lumbar regions and an expanded neuroepithelium
• E10.5 or older embryos show a drastic increase in the expansion of the neural canal (enlarged lumen) and a neuroepithelium with a higher cell density
• exhibit an increase in apoptotic cells in the dorsal and lateral regions of the neural tube
|
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• E9.5-E10.5 embryos exhibit an expanded neuroepithelium with a higher cell density
|
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• at the thoracic and lumbar regions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all double mutants found at E8.5 to E10.5 are in various stages of resorption, indicating early embryonic lethality
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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