Phenotypes associated with this allele

• Allele Symbol: Plscr1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:2180949
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plscr1^tm1Lex/Plscr1^tm1Lex	129S/SvEvBrd-Plscr1^tm1Lex	MGI:3041457
cx2	Plscr1^tm1Lex/Plscr1^tm1Lex Plscr3^tm1Sims/Plscr3^tm1Sims	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3053804

Genotype
MGI:3041457

hm1

• Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex
• Genetic Background: 129S/SvEvBrd-Plscr1^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased fat cell size ( J:92404 )

• increase in size of adipocytes

abnormal fat pad morphology ( J:92404 )

• modest increase in fat pad size

hematopoietic system

abnormal myelopoiesis ( J:76790 )

• myelopoiesis is normal in adults but is defective in neonates

abnormal granulocyte differentiation ( J:76790 )

• lower levels of granulocytes are produced in response to stimulation with either granulocyte-colony stimulating factor or stem cell factor; also more immature cells are found

abnormal neutrophil differentiation ( J:76790 )

• neutrophil levels resulting from treatment with granulocyte-colony stimulating factor are considerably lower than in control mice

decreased granulocyte number ( J:76790 )

• newborns have fewer Gr-1 granulocytes in the liver

decreased neutrophil cell number ( J:76790 )

• reduced numbers of neutrophiles are found in newborns

immune system

abnormal myelopoiesis ( J:76790 )

• myelopoiesis is normal in adults but is defective in neonates

abnormal granulocyte differentiation ( J:76790 )

• lower levels of granulocytes are produced in response to stimulation with either granulocyte-colony stimulating factor or stem cell factor; also more immature cells are found

abnormal neutrophil differentiation ( J:76790 )

• neutrophil levels resulting from treatment with granulocyte-colony stimulating factor are considerably lower than in control mice

decreased granulocyte number ( J:76790 )

• newborns have fewer Gr-1 granulocytes in the liver

decreased neutrophil cell number ( J:76790 )

• reduced numbers of neutrophiles are found in newborns

cellular

abnormal granulocyte differentiation ( J:76790 )

• lower levels of granulocytes are produced in response to stimulation with either granulocyte-colony stimulating factor or stem cell factor; also more immature cells are found

abnormal neutrophil differentiation ( J:76790 )

• neutrophil levels resulting from treatment with granulocyte-colony stimulating factor are considerably lower than in control mice

Genotype
MGI:3053804

cx2

• Allelic Composition: Plscr1^tm1Lex/Plscr1^tm1Lex; Plscr3^tm1Sims/Plscr3^tm1Sims
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

hematopoietic system

abnormal myelopoiesis ( J:92404 )

• bone marrow cells exhibit impaired maturation in response to growth factors

homeostasis/metabolism

impaired glucose tolerance ( J:92404 )

• glucose intolerance by two months of age

abnormal lipid homeostasis ( J:92404 )

• increase in size and number of lipid droplets in bone marrow derived granulocytes and macrophages

immune system

abnormal myelopoiesis ( J:92404 )

• bone marrow cells exhibit impaired maturation in response to growth factors