Phenotypes associated with this allele

• Allele Symbol: Sstr2^tm1Bne
• Allele Name: targeted mutation 1, Babraham Neuroendocrinology
• Allele ID: MGI:2181022
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sstr2^tm1Bne/Sstr2^tm1Bne	involves: 129P2/OlaHsd * C57BL/6	MGI:3615659

Genotype
MGI:3615659

hm1

• Allelic Composition: Sstr2^tm1Bne/Sstr2^tm1Bne
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:75873 )

N • homozygotes display no significant differences in jejunal contractile activity, as shown by normal migrating motor complex properties (MMCs) evoked by distension (intraluminal pressure 2.5-3.5 cmH2O) relative to wild-type mice

N • notably, both agonist BIM-23027 and SRIF (somatotropin release-inhibitory factor) significantly increase the interval between MMCs in wild-type jejunum, but only SRIF is effective in mutant jejunum, indicating that an additional receptor subtype is involved in the regulation of intestinal peristalsis