Analysis Tools
immune system
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• at 6 weeks of age, homozygotes are appear normal and healthy, and display normal immune cell development and differentiation relative to wild-type mice, as indicated by FACS analysis of spleen, lymph node, and thymic cells
• no significant differences are noted in the proportion of macrophages within the peritoneal population, as quantified by Mac-1 expression
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• in a T cell co-stimulation assay, peritoneal macrophages derived from homozygous mutant mice are completely resistant to delta9-tetrahydrocannabinol inhibition of co-stimulatory activity and hence T cell activation, as evidenced by the drug's failure to suppress IL-2 production by helper T cells
• however, homozygotes normal delta9-tetrahydrocannabinol-induced hypothermia and catalepsy, indicating that the CNS effects of cannabinoids, thought to be mediated by cannabinoid receptor 1 (brain), are not altered
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hematopoietic system
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• in a T cell co-stimulation assay, peritoneal macrophages derived from homozygous mutant mice are completely resistant to delta9-tetrahydrocannabinol inhibition of co-stimulatory activity and hence T cell activation, as evidenced by the drug's failure to suppress IL-2 production by helper T cells
• however, homozygotes normal delta9-tetrahydrocannabinol-induced hypothermia and catalepsy, indicating that the CNS effects of cannabinoids, thought to be mediated by cannabinoid receptor 1 (brain), are not altered
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