mortality/aging
• homozygous mice die within 15 minutes of birth
|
behavior/neurological
trunk curl
(
J:69625
)
• abnormal flexor and extensor posturing at E18.5
|
• E18.5 embryos react only to strong mechanical stimuli
|
respiratory system
atelectasis
(
J:69625
)
• lungs fail to expand completely
|
• newborn mice failed to breathe
|
nervous system
• inspiratory motor output of brainstem lacked rhythmicity found in control animals
|
• spontaneous motoneuron action potentials are frequent in the sciatic nerve
• 98% probability of on action potential spike being followed by another within 5 seconds
|
• function of alpha motoneurons disrupted
• increased level of nerve depolarization
|
growth/size/body
• abdominal wall defects
• increased prominance
|
omphalocele
(
J:69625
)
• intestinal protrusion at the umbilicus frequently seen
|