Phenotypes associated with this allele

• Allele Symbol: Cntfr^tm1Gdy
• Allele Name: targeted mutation 1, George D Yancopoulos
• Allele ID: MGI:2181046
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cntfr^tm1Gdy/Cntfr^tm1Gdy	involves: 129P2/OlaHsd * C57BL/6	MGI:2663854

Genotype
MGI:2663854

hm1

• Allelic Composition: Cntfr^tm1Gdy/Cntfr^tm1Gdy
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:29357 )

behavior/neurological

absent suckling reflex ( J:29357 )

• newborn mutants fail to suckle

nervous system

small facial motor nucleus ( J:29357 )

• 41% reduction in the facial motor nucleus

small trigeminal motor nucleus ( J:29357 )

• 27% reduction in the trigeminal motor nucleus

abnormal motor neuron morphology ( J:29357 )

• 12% reduction in the cross-sectional area of spinal cord motor neurons

decreased motor neuron number ( J:29357 )

• reduced number of motor neurons in the facial motor nucleus, trigeminal motor nucleus, hypoglossal motor nucleus, and spinal cord