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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bmp4tm3Blh
targeted mutation 3, Brigid L Hogan
MGI:2181188
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bmp4tm3Blh/Bmp4tm3Blh involves: 129S6/SvEvTac MGI:3811332
hm2
 		Bmp4tm3Blh/Bmp4tm3Blh involves: 129S6/SvEvTac * Black Swiss MGI:2183178
ht3
 		Bmp4tm3Blh/Bmp4+ involves: 129S6/SvEvTac MGI:3811333
cn4
 		Bmp4tm3Blh/Bmp4tm3Blh
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:2661104
cn5
 		Bmp4tm3Blh/Bmp4+
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3811334


Genotype
MGI:3811332
hm1
Allelic
Composition		 Bmp4tm3Blh/Bmp4tm3Blh
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3Blh mutation (0 available); any Bmp4 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:83123 )
• significant loss of embryos between E12.5 and E14.5

vision/eye
abnormal eye development ( J:83123 )
• severely deficient




Genotype
MGI:2183178
hm2
Allelic
Composition		 Bmp4tm3Blh/Bmp4tm3Blh
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3Blh mutation (0 available); any Bmp4 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:75136 )
• less than half of animals survive until weaning

behavior/neurological
circling ( J:75136 )
• extreme circling behavior

vision/eye




Genotype
MGI:3811333
ht3
Allelic
Composition		 Bmp4tm3Blh/Bmp4+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3Blh mutation (0 available); any Bmp4 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:83123 )
• fewer mice survive to birth than expected




Genotype
MGI:2661104
cn4
Allelic
Composition		 Bmp4tm3Blh/Bmp4tm3Blh
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3Blh mutation (0 available); any Bmp4 mutation (23 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:83123 )
• all die between E12.5 and E14.5
• only necrotic embryos are found at E14.5

craniofacial
retrognathia ( J:83123 )
• recessed jaws
abnormal snout morphology ( J:83123 )
• recessed snout

vision/eye
abnormal eye development ( J:83123 )
• severely deficient

nervous system
nervous system phenotype ( J:83123 )
N
• despite Cre-mediated deletion in the telencephalon, no defects in telencephalic patterning or development are detected

skeleton
retrognathia ( J:83123 )
• recessed jaws

growth/size/body
abnormal face development ( J:83123 )
abnormal snout morphology ( J:83123 )
• recessed snout




Genotype
MGI:3811334
cn5
Allelic
Composition		 Bmp4tm3Blh/Bmp4+
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3Blh mutation (0 available); any Bmp4 mutation (23 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:83123 )
• fewer mice survive to birth than expected




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory