Phenotypes associated with this allele

• Allele Symbol: Cox6a2^tm1Djg
• Allele Name: targeted mutation 1, Daniel J Garry
• Allele ID: MGI:2181189
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cox6a2^tm1Djg/Cox6a2^tm1Djg	involves: 129S4/SvJae * C57BL/6	MGI:3038743

Genotype
MGI:3038743

hm1

• Allelic Composition: Cox6a2^tm1Djg/Cox6a2^tm1Djg
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:75606 )

N • analysis of myocardial tissue revealed no structural differences between mutant and wild-type cardiac muscle

N • mutant hearts exhibited neither pericardial abnormalities nor increases in intramyocardial fibrosis

N • ultrastructural assessment of adult wild-type and mutant hearts revealed no qualitative differences in basic cellular ultrastructure including mitochondrial morphology, size, or number per cell

N • echocardiography revealed the presence of normal left ventricular systolic function in homozygous null hearts

N • standard biochemical methods and spectroscopy of isolated working hearts indicated no differences in pH, sugar phosphates, or total myocardial ATP concentration between wild-type and mutant hearts

abnormal cardiovascular system physiology ( J:75606 )

• total COX activity was decreased in hearts from homozygous null mice

decreased diastolic filling velocity ( J:75606 )

• homozygous null hearts exhibited impaired left ventricular filling or diastolic dysfunction under maximal cardiac load, in the absence of systolic dysfunction