Phenotypes associated with this allele

• Allele Symbol: Calb1^tm2.1Mpin
• Allele Name: targeted mutation 2.1, Max-Planck-Institute for Neurobiology
• Allele ID: MGI:2181196
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Calb1^tm2.1Mpin/Calb1^tm2.1Mpin	involves: 129S1/Sv * 129X1/SvJ	MGI:3848702
cn2	Calb1^tm2.1Mpin/Calb1^tm2.1Mpin Tg(Pcp2-cre)2Mpin/?	involves: 129S1/Sv * 129X1/SvJ	MGI:3848703

Genotype
MGI:3848702

hm1

• Allelic Composition: Calb1^tm2.1Mpin/Calb1^tm2.1Mpin
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:75111 )

N • no behavioral abnormalities are detected in the open field and runway tests

Genotype
MGI:3848703

cn2

• Allelic Composition: Calb1^tm2.1Mpin/Calb1^tm2.1Mpin; Tg(Pcp2-cre)2Mpin/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

behavior/neurological

abnormal reflex ( J:83378 )

• reduced gain of the optokinetic reflex at all stimulus frequencies tested

• however, the phase values do not differ from controls

abnormal vestibuloocular reflex ( J:83378 )

• reduced gain of the vestibuloocular reflex in the light at all stimulus frequencies tested

• however, the phase values do not differ from controls and no difference was detected in this reflex in the dark

impaired limb coordination ( J:83378 )

• increase in the number of foot slips in a runway test even after prolonged training

• impaired ability to stay on a stationary bar

nervous system

nervous system phenotype ( J:83378 )

N • despite loss of expression in Purkinje cells no defect in long term depression is detected

abnormal neuron physiology ( J:83378 )

• following single shock parallel fiber activation early synaptic calcium transients are 2 to 3 times larger and their decay constants are 3 to 4 times shorter compared to controls

• following single shock activation of climbing fibers the amplitude of fast synaptic calcium transients is increased by about 80% and the decay time constant is reduced by greater than 50%

hearing/vestibular/ear

abnormal vestibuloocular reflex ( J:83378 )

• reduced gain of the vestibuloocular reflex in the light at all stimulus frequencies tested

• however, the phase values do not differ from controls and no difference was detected in this reflex in the dark