Phenotypes associated with this allele

• Allele Symbol: Serpinf2^tm1Hrl
• Allele Name: targeted mutation 1, H Roger Lijnen
• Allele ID: MGI:2181226
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Serpinf2^tm1Hrl/Serpinf2^tm1Hrl	involves: 129X1/SvJ * C57BL/6J	MGI:2672889

Genotype
MGI:2672889

hm1

• Allelic Composition: Serpinf2^tm1Hrl/Serpinf2^tm1Hrl
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:54047 )

• less endotoxin induced fibrin deposition in the kidney

abnormal thrombolysis ( J:54047 )

• higher frequency of spontaneous clot lysis

decreased cerebral infarct size ( J:55243 )

• following ligation of the middle cerebral artery, cerebral ischemic infarct size is much smaller

nervous system

decreased cerebral infarct size ( J:55243 )

• following ligation of the middle cerebral artery, cerebral ischemic infarct size is much smaller

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha-2-plasmin inhibitor deficiency		DOID:0060601	OMIM:262850	J:54047 , J:55243