Phenotypes associated with this allele

• Allele Symbol: Csf2rb^tm1Mur
• Allele Name: targeted mutation 1, Richard Murray
• Allele ID: MGI:2181261
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csf2rb^tm1Mur/Csf2rb^tm1Mur	involves: 129P2/OlaHsd	MGI:3604114
hm2	Csf2rb^tm1Mur/Csf2rb^tm1Mur	involves: 129P2/OlaHsd * C57BL/6	MGI:3604113
cx3	Csf2rb^tm1Mur/Csf2rb^tm1Mur Il3^tm1Tyb/Il3^tm1Tyb	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3604115

Genotype
MGI:3604114

hm1

• Allelic Composition: Csf2rb^tm1Mur/Csf2rb^tm1Mur
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased eosinophil cell number ( J:24122 )

• the number of eosinophils in the peripheral blood is reduced; however, the number of other peripheral blood cells, bone marrow, spleen, and peritoneal cells are all normal

abnormal eosinophil physiology ( J:24122 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, serum IgE levels are increased after infection

lung inflammation ( J:24122 )

• peribronchovascular lymphocytic infiltration

increased susceptibility to infection ( J:24122 )

• no eosinophilia or pulmonary granulomatous lesions are seen 14 days after infection with the nematode, N brasiliensis; however severe lung edema and diffuse infiltration of mononuclear cells and neutrophils are seen and 21 days after infection lung inflammation persists

respiratory system

lung inflammation ( J:24122 )

• peribronchovascular lymphocytic infiltration

abnormal pulmonary alveolus morphology ( J:24122 )

• a focal but scattered intraalveolar proteinacious substance is seen associated with expanded foamy pulmonary alveolar macrophages

hematopoietic system

abnormal myeloblast morphology/development ( J:24122 )

• no colonies are formed in vitro in the presence of granulocyte-macrophage colony-stimulating factor or IL-5

decreased eosinophil cell number ( J:24122 )

• the number of eosinophils in the peripheral blood is reduced; however, the number of other peripheral blood cells, bone marrow, spleen, and peritoneal cells are all normal

abnormal eosinophil physiology ( J:24122 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, serum IgE levels are increased after infection

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary alveolar proteinosis		DOID:12120	OMIM:265120 OMIM:300770 OMIM:610913 OMIM:610921 OMIM:614370	J:24122

Genotype
MGI:3604113

hm2

• Allelic Composition: Csf2rb^tm1Mur/Csf2rb^tm1Mur
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

decreased eosinophil cell number ( J:35829 )

• the number of eosinophils in the peripheral blood is reduced

abnormal eosinophil physiology ( J:35829 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, response to bacterial infection and hematopoietic cell recovery after treatment with a cytotoxic agent are normal

lung inflammation ( J:35829 )

• peribronchovascular lymphocytic infiltration

respiratory system

lung inflammation ( J:35829 )

• peribronchovascular lymphocytic infiltration

abnormal pulmonary alveolus morphology ( J:35829 )

• a focal but scattered intraalveolar proteinacious substance is seen associated with expanded foamy pulmonary alveolar macrophages

hematopoietic system

abnormal myeloblast morphology/development ( J:35829 )

• no colonies are formed in vitro in the presence of granulocyte-macrophage colony-stimulating factor or IL-5

decreased eosinophil cell number ( J:35829 )

• the number of eosinophils in the peripheral blood is reduced

abnormal eosinophil physiology ( J:35829 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, response to bacterial infection and hematopoietic cell recovery after treatment with a cytotoxic agent are normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary alveolar proteinosis		DOID:12120	OMIM:265120 OMIM:300770 OMIM:610913 OMIM:610921 OMIM:614370	J:35829

Genotype
MGI:3604115

cx3

• Allelic Composition: Csf2rb^tm1Mur/Csf2rb^tm1Mur; Il3^tm1Tyb/Il3^tm1Tyb
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

immune system

decreased eosinophil cell number ( J:35829 )

• the number of eosinophils in the peripheral blood is reduced; however, the number of peritoneal and gastrointestinal mast cells, other peripheral blood cells, bone marrow, spleen, and peritoneal cells are all normal

abnormal eosinophil physiology ( J:35829 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, response to bacterial infection and hematopoietic cell recovery after treatment with a cytotoxic agent are normal

lung inflammation ( J:35829 )

• peribronchovascular lymphocytic infiltration

• severity and progress of inflammation are similar to that in Csf2rb1 single homozygotes

respiratory system

lung inflammation ( J:35829 )

• peribronchovascular lymphocytic infiltration

• severity and progress of inflammation are similar to that in Csf2rb1 single homozygotes

abnormal pulmonary alveolus morphology ( J:35829 )

• a focal but scattered intraalveolar proteinacious substance is seen associated with expanded foamy pulmonary alveolar macrophages

hematopoietic system

abnormal myeloblast morphology/development ( J:35829 )

• no colonies are formed in vitro in the presence of granulocyte-macrophage colony-stimulating factor or IL-5

decreased eosinophil cell number ( J:35829 )

• the number of eosinophils in the peripheral blood is reduced; however, the number of peritoneal and gastrointestinal mast cells, other peripheral blood cells, bone marrow, spleen, and peritoneal cells are all normal

abnormal eosinophil physiology ( J:35829 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, response to bacterial infection and hematopoietic cell recovery after treatment with a cytotoxic agent are normal