All Phenotypes Ptprc<tm1Mak> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptprc^tm1Mak
targeted mutation 1, Tak W Mak
MGI:2181288

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprc^tm1Mak/Ptprc^tm1Mak	B6.Cg-Ptprc^tm1Mak	MGI:4834471
hm2	Ptprc^tm1Mak/Ptprc^tm1Mak	involves: 129	MGI:4834359
hm3	Ptprc^tm1Mak/Ptprc^tm1Mak	involves: 129/Sv * C57BL/6	MGI:4442179
ht4	Ptprc^ltng/Ptprc^tm1Mak	involves: 129/Sv * C57BL/6	MGI:4442177
cx5	Ptprc^tm1Mak/Ptprc^tm1Mak Ptprj^tm1.2Weis/Ptprj^tm1.2Weis	B6.Cg-Ptprc^tm1Mak Ptprj^tm1.2Weis	MGI:3774857
cx6	Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^tm1Mak	involves: 129S7/SvEvBrd * C57BL/6	MGI:4442178
cx7	Ptprc^tm1Mak/Ptprc^tm1Mak Ptprj^tm1.2Weis/Ptprj^tm1.2Weis	involves: 129/Sv * 129P2/OlaHsd * BALB/cJ * C57BL/6	MGI:3774856
cx8	Ptprc^tm1Mak/Ptprc^tm1Mak Tg(TcraTcrb)425Cbn/0	involves: 129/Sv * BALB/c * C57BL/6	MGI:4442181
cx9	Ptprc^ltng/Ptprc^tm1Mak Tg(TcraTcrb)425Cbn/0	involves: 129/Sv * BALB/c * C57BL/6	MGI:4442182

Allelic Composition	Ptprc^tm1Mak/Ptprc^tm1Mak
Genetic Background	B6.Cg-Ptprc^tm1Mak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprc^tm1Mak mutation (2 available); any Ptprc mutation (189 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) exhibit increased spontaneous apoptosis compared to in wild-type mice

• gamma-delta iIELs are more susceptible to induction of apoptosis compared with alpha-beta iIELs

abnormal T cell differentiation ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell morphology ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) are slightly larger than wild-type cells

• in reconstitution experiments, intrathymic development of iIELs is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell number ( J:111646 )

• at 10 weeks, the number of intestinal intraepithelial lymphocytes (iIELs) is increased 1.5- to 2-fold compared to in wild-type mice

• at 10 weeks, the number of CD4+CD8- alpha-beta iIELs is increased 7-fold compared to in wild-type mice

• the number of iIELs decrease over time unlike in wild-type mice that exhibit an increase in these cells

• at 20 weeks, iIELs are decreased compared to in wild-type mice

decreased gamma-delta intraepithelial T cell number ( J:111646 )

• at 10 and 20 weeks, mice exhibit decreased gamma-delta intestinal intraepithelial lymphocytes, which continue to decrease in number with age, compared with wild-type mice

abnormal CD4-positive, alpha-beta intraepithelial T cell morphology ( J:111646 )

• at 10 weeks, the number of CD4+CD8- alpha-beta intestinal intraepithelial lymphocytes is increased 7-fold compared to in wild-type mice

abnormal NK cell physiology ( J:109462 )

• NK cells stimulated with ligands to or antibodies against NK1.1, CD16, Ly49H, Ly49D, and NKG2D exhibit reduced cytokine secretion compared with similarly treated wild-type cells

• however, NK cell cytotoxicity in response to ITAM receptor stimulation is normal

decreased cytotoxic T cell cytolysis ( J:111646 )

• intestinal intraepithelial lymphocytes exhibit impaired cytolytic activities compared with wild-type cells

hematopoietic system

increased T cell apoptosis ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) exhibit increased spontaneous apoptosis compared to in wild-type mice

• gamma-delta iIELs are more susceptible to induction of apoptosis compared with alpha-beta iIELs

abnormal T cell differentiation ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell morphology ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) are slightly larger than wild-type cells

• in reconstitution experiments, intrathymic development of iIELs is impaired

• however, extrathymic development of iIELs is normal in reconstitution experiments

abnormal intraepithelial T cell number ( J:111646 )

• at 10 weeks, the number of intestinal intraepithelial lymphocytes (iIELs) is increased 1.5- to 2-fold compared to in wild-type mice

• at 10 weeks, the number of CD4+CD8- alpha-beta iIELs is increased 7-fold compared to in wild-type mice

• the number of iIELs decrease over time unlike in wild-type mice that exhibit an increase in these cells

• at 20 weeks, iIELs are decreased compared to in wild-type mice

decreased gamma-delta intraepithelial T cell number ( J:111646 )

• at 10 and 20 weeks, mice exhibit decreased gamma-delta intestinal intraepithelial lymphocytes, which continue to decrease in number with age, compared with wild-type mice

abnormal CD4-positive, alpha-beta intraepithelial T cell morphology ( J:111646 )

• at 10 weeks, the number of CD4+CD8- alpha-beta intestinal intraepithelial lymphocytes is increased 7-fold compared to in wild-type mice

abnormal NK cell physiology ( J:109462 )

• NK cells stimulated with ligands to or antibodies against NK1.1, CD16, Ly49H, Ly49D, and NKG2D exhibit reduced cytokine secretion compared with similarly treated wild-type cells

• however, NK cell cytotoxicity in response to ITAM receptor stimulation is normal

decreased cytotoxic T cell cytolysis ( J:111646 )

• intestinal intraepithelial lymphocytes exhibit impaired cytolytic activities compared with wild-type cells

cellular

increased T cell apoptosis ( J:111646 )

• intestinal intraepithelial lymphocytes (iIELs) exhibit increased spontaneous apoptosis compared to in wild-type mice

• gamma-delta iIELs are more susceptible to induction of apoptosis compared with alpha-beta iIELs

Allelic Composition	Ptprc^tm1Mak/Ptprc^tm1Mak
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprc^tm1Mak mutation (2 available); any Ptprc mutation (189 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mast cell degranulation ( J:110782 )

• IgE monoclonal anti-DNP antibody primed mast cells are incapable of significant degranulation unlike similarly treated wild-type cells

• however, cells exhibit normal

abnormal osteoclast morphology ( J:141275 )

abnormal osteoclast physiology ( J:141275 )

• osteoclasts exhibit impaired bone remodeling compared with wild-type cells

decreased susceptibility to type I hypersensitivity reaction ( J:110782 )

• mice are resistant to IgE-mediated anaphylaxis unlike wild-type mice

nervous system

abnormal oligodendrocyte morphology ( J:104929 )

• oligodendrocyte precursor cells fail to differentiate in the presence of IgG or anti-Fcrg antibodies unlike wild-type cells

decreased oligodendrocyte number ( J:104929 )

• at P10

abnormal myelination ( J:104929 )

• at P10

skeleton

abnormal osteoclast morphology ( J:141275 )

abnormal osteoclast physiology ( J:141275 )

• osteoclasts exhibit impaired bone remodeling compared with wild-type cells

abnormal long bone metaphysis morphology ( J:141275 )

• metaphyseal bone trabecules are irregularly distributed compared to in wild-type mice

hematopoietic system

decreased mast cell degranulation ( J:110782 )

• IgE monoclonal anti-DNP antibody primed mast cells are incapable of significant degranulation unlike similarly treated wild-type cells

• however, cells exhibit normal

abnormal bone marrow cell morphology/development ( J:141275 )

• bone marrow leukocytes exhibit defective motility, progenitor cell expansion, homing, and mobilization by colony-stimulating factor (G-CSF) and increased cell adhesion compared with wild-type cells

abnormal osteoclast morphology ( J:141275 )

abnormal osteoclast physiology ( J:141275 )

• osteoclasts exhibit impaired bone remodeling compared with wild-type cells

cellular

decreased mast cell degranulation ( J:110782 )

• IgE monoclonal anti-DNP antibody primed mast cells are incapable of significant degranulation unlike similarly treated wild-type cells

• however, cells exhibit normal

Allelic Composition	Ptprc^tm1Mak/Ptprc^tm1Mak
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprc^tm1Mak mutation (2 available); any Ptprc mutation (189 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell proliferation ( J:13163 )

• in response to anti-mu

• however, LPS activated B cell proliferation is normal

decreased T cell proliferation ( J:13163 )

• following stimulation with lection and TCR-CD3 cross-linking

increased double-negative T cell number ( J:13163 )

arrested T cell differentiation ( J:158876 )

• the transition from double positive to single positive is blocked unlike in wild-type mice

abnormal T cell subpopulation ratio ( J:13163 )

• the ratio of CD8+ to CD4+ T cells is skewed towards CD4+ T cells unlike in wild-type mice

decreased T cell number ( J:13163 )

• in the spleen, lymph nodes, and bone marrow with CD8+ T cells reduced to a greater extent than CD4+ T cells

decreased thymocyte number ( J:13163 )

• slightly

decreased CD4-positive, alpha-beta T cell number ( J:13163 )

decreased CD8-positive, alpha-beta T cell number ( J:13163 )

decreased cytotoxic T cell cytolysis ( J:13163 )

• in mice exposed to lymphocytic choriomeningitis virus (LCMV)

abnormal response to infection ( J:13163 )

• mice exposed to lymphocytic choriomeningitis virus (LCMV) fail to exhibit a T cell cytotoxic response unlike similarly treated wild-type mice

• however, mice challenged with vesicular stomatitis virus exhibit normal IgM and IgG production

hematopoietic system

decreased B cell proliferation ( J:13163 )

• in response to anti-mu

• however, LPS activated B cell proliferation is normal

decreased T cell proliferation ( J:13163 )

• following stimulation with lection and TCR-CD3 cross-linking

increased double-negative T cell number ( J:13163 )

arrested T cell differentiation ( J:158876 )

• the transition from double positive to single positive is blocked unlike in wild-type mice

abnormal T cell subpopulation ratio ( J:13163 )

• the ratio of CD8+ to CD4+ T cells is skewed towards CD4+ T cells unlike in wild-type mice

decreased T cell number ( J:13163 )

• in the spleen, lymph nodes, and bone marrow with CD8+ T cells reduced to a greater extent than CD4+ T cells

decreased thymocyte number ( J:13163 )

• slightly

decreased CD4-positive, alpha-beta T cell number ( J:13163 )

decreased CD8-positive, alpha-beta T cell number ( J:13163 )

decreased cytotoxic T cell cytolysis ( J:13163 )

• in mice exposed to lymphocytic choriomeningitis virus (LCMV)

endocrine/exocrine glands

decreased thymocyte number ( J:13163 )

• slightly

cellular

decreased B cell proliferation ( J:13163 )

• in response to anti-mu

• however, LPS activated B cell proliferation is normal

decreased T cell proliferation ( J:13163 )

• following stimulation with lection and TCR-CD3 cross-linking

Allelic Composition	Ptprc^ltng/Ptprc^tm1Mak
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprc^ltng mutation (3 available); any Ptprc mutation (189 available)
Ptprc^tm1Mak mutation (2 available); any Ptprc mutation (189 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:158876 )

abnormal T cell differentiation ( J:158876 )

• mice exhibit enhanced negative selection compared with wild-type mice

• positive selection of T cell is rescued and single positive thymic subsets compared to in Ptprc^tm1Mak homozygotes

decreased double-positive T cell number ( J:158876 )

decreased CD4-positive, alpha-beta T cell number ( J:158876 )

• SP4 thymocytes are reduced compared to in wild-type mice

hematopoietic system

thymus hypoplasia ( J:158876 )

abnormal T cell differentiation ( J:158876 )

• mice exhibit enhanced negative selection compared with wild-type mice

• positive selection of T cell is rescued and single positive thymic subsets compared to in Ptprc^tm1Mak homozygotes

decreased double-positive T cell number ( J:158876 )

decreased CD4-positive, alpha-beta T cell number ( J:158876 )

• SP4 thymocytes are reduced compared to in wild-type mice

endocrine/exocrine glands

thymus hypoplasia ( J:158876 )

Allelic Composition	Ptprc^tm1Mak/Ptprc^tm1Mak Ptprj^tm1.2Weis/Ptprj^tm1.2Weis
Genetic Background	B6.Cg-Ptprc^tm1Mak Ptprj^tm1.2Weis

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprc^tm1Mak mutation (2 available); any Ptprc mutation (189 available)
Ptprj^tm1.2Weis mutation (2 available); any Ptprj mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:131736 )

• mice die prematurely between 25 and 65 days of age

• Background Sensitivity: double mutants on mixed background (3 or less backcrosses to C57BL/6) show increased lifespan generally reaching 6 months of age and remaining healthy until 2 months of age, compared to accelerated phenotype of congenic mutants

growth/size/body

decreased body weight ( J:131736 )

• double null mice are significantly underweight (60% of weight of wild-type mice)

hematopoietic system

abnormal B cell differentiation ( J:131736 )

• pre B cell numbers are similar in double null and wild-type mice, but few B cells develop further to CD19+ CD43- B cells

decreased immature B cell number ( J:131736 )

• immature IgM+ IgD- B cells are decreased in number in the bone marrow

abnormal transitional stage B cell morphology ( J:131736 )

• there is a higher proportion of transitional stage B cells, but absolute B cell number is decreased

abnormal myelopoiesis ( J:131736 )

• spleens contain a cell population expressing CD19 but not IgM of IgD; cells are slightly bigger than normal B cells

• Background Sensitivity: myeloproliferative disorder with extramedullary hematopoiesis develops in congenic mice earlier than mice on mixed background

extramedullary hematopoiesis ( J:131736 )

• prior to death, mice develop a myeloproliferative disorder and show extramedullary hematopoiesis

anemia ( J:131736 )

• pre-terminal animals show varying degrees of anemia

decreased B cell number ( J:131736 )

• B cell lymphopenia develops; total cell numbers in spleens and lymph nodes are substatiantially lower than in wild-type mice or either single mutant homozygotes

• marked decreases in B cell numbers and percentages are observed in the bone marrow relative to controls

decreased mature B cell number ( J:131736 )

• practically no recirculating mature IgM+ IgD+ B cells are detected in the bone marrow

abnormal follicular B cell morphology ( J:131736 )

• in double mutants on mixed background, follicular lymph node B cells express higher amounts of IgM than wild-type or Ptprj^tm1.2Weis cells

abnormal spleen morphology ( J:131736 )

• mice develop myeloproliferative disorder and show distortion of splenic architecture

immune system

abnormal B cell differentiation ( J:131736 )

• pre B cell numbers are similar in double null and wild-type mice, but few B cells develop further to CD19+ CD43- B cells

decreased immature B cell number ( J:131736 )

• immature IgM+ IgD- B cells are decreased in number in the bone marrow

abnormal transitional stage B cell morphology ( J:131736 )

• there is a higher proportion of transitional stage B cells, but absolute B cell number is decreased

abnormal myelopoiesis ( J:131736 )

• spleens contain a cell population expressing CD19 but not IgM of IgD; cells are slightly bigger than normal B cells

• Background Sensitivity: myeloproliferative disorder with extramedullary hematopoiesis develops in congenic mice earlier than mice on mixed background

decreased B cell number ( J:131736 )

• B cell lymphopenia develops; total cell numbers in spleens and lymph nodes are substatiantially lower than in wild-type mice or either single mutant homozygotes

• marked decreases in B cell numbers and percentages are observed in the bone marrow relative to controls

decreased mature B cell number ( J:131736 )

• practically no recirculating mature IgM+ IgD+ B cells are detected in the bone marrow

abnormal follicular B cell morphology ( J:131736 )

• in double mutants on mixed background, follicular lymph node B cells express higher amounts of IgM than wild-type or Ptprj^tm1.2Weis cells

abnormal spleen morphology ( J:131736 )

• mice develop myeloproliferative disorder and show distortion of splenic architecture

liver inflammation ( J:131736 )

• extensive myeloid infiltration of liver is observed

lung inflammation ( J:131736 )

• scattered myeloid infiltrates are detected in the lungs

liver/biliary system

liver inflammation ( J:131736 )

• extensive myeloid infiltration of liver is observed

respiratory system

lung inflammation ( J:131736 )

• scattered myeloid infiltrates are detected in the lungs

Allelic Composition	Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^tm1Mak
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csk^tm1Sor mutation (2 available); any Csk mutation (27 available)
Ptprc^ltng mutation (3 available); any Ptprc mutation (189 available)
Ptprc^tm1Mak mutation (2 available); any Ptprc mutation (189 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:158876 )

abnormal T cell differentiation ( J:158876 )

• ligand-independent signaling checkpoint in T cell development is rescued compared to in Ptprc^ltng/Ptprc^tm1Mak heterozygotes and comparable to in Ptprc^ltng homozygotes

hematopoietic system

thymus hypoplasia ( J:158876 )

abnormal T cell differentiation ( J:158876 )

• ligand-independent signaling checkpoint in T cell development is rescued compared to in Ptprc^ltng/Ptprc^tm1Mak heterozygotes and comparable to in Ptprc^ltng homozygotes

endocrine/exocrine glands

thymus hypoplasia ( J:158876 )

Allelic Composition	Ptprc^tm1Mak/Ptprc^tm1Mak Ptprj^tm1.2Weis/Ptprj^tm1.2Weis
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * BALB/cJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal B cell calcium ion homeostasis ( J:131736 )

• B cells show delayed calcium ion flux after B cell receptor crosslinking compared to wild-type and single null mice at 6-8 weeks of age

mortality/aging

premature death ( J:131736 )

• Background Sensitivity: on mixed background, mice live until 6 months and remain healthy until 2 months of age, compared to mice on congenic background which display earlier lethality and accelerated B cell phenotype

hematopoietic system

impaired macrophage phagocytosis ( J:131736 )

• Fc receptor mediated phagocytosis by bone marrow-derived macrophages is decreased by 40% relative to wild-type

abnormal myelopoiesis ( J:131736 )

• Background Sensitivity: on mixed background, myeloproliferative disorder in mice is delayed in development compared to congenic mutants

decreased B cell number ( J:131736 )

• Background Sensitivity: young mice on mixed background show mild reduction in B cell number whereas reduction becomes more severe on congenic C57BL/6 background; B cell lymphopenia develops due to profound block at pre-B cell stage of development in the bone marrow

abnormal follicular B cell morphology ( J:131736 )

• in double mutants on mixed background, follicular lymph node B cells express higher amounts of IgM than wild-type or Ptprj^tm1.2Weis cells

abnormal B cell calcium ion homeostasis ( J:131736 )

• B cells show delayed calcium ion flux after B cell receptor crosslinking compared to wild-type and single null mice at 6-8 weeks of age

immune system

impaired macrophage phagocytosis ( J:131736 )

• Fc receptor mediated phagocytosis by bone marrow-derived macrophages is decreased by 40% relative to wild-type

abnormal myelopoiesis ( J:131736 )

• Background Sensitivity: on mixed background, myeloproliferative disorder in mice is delayed in development compared to congenic mutants

decreased B cell number ( J:131736 )

abnormal follicular B cell morphology ( J:131736 )

• in double mutants on mixed background, follicular lymph node B cells express higher amounts of IgM than wild-type or Ptprj^tm1.2Weis cells

abnormal B cell calcium ion homeostasis ( J:131736 )

• B cells show delayed calcium ion flux after B cell receptor crosslinking compared to wild-type and single null mice at 6-8 weeks of age

abnormal cytokine secretion ( J:131736 )

• Fc receptor-induced tumor necrosis factor alpha production (Tnfa) by bone marrow-derived macrophages in double mutant mice

• after LPS treatment Tnfa production by macrophages is equivalent to wild-type cells

cellular

impaired macrophage phagocytosis ( J:131736 )

• Fc receptor mediated phagocytosis by bone marrow-derived macrophages is decreased by 40% relative to wild-type

Allelic Composition	Ptprc^tm1Mak/Ptprc^tm1Mak Tg(TcraTcrb)425Cbn/0
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprc^tm1Mak mutation (2 available); any Ptprc mutation (189 available)
Tg(TcraTcrb)425Cbn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:158876 )

• nearly absent

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:158876 )

• nearly absent

Allelic Composition	Ptprc^ltng/Ptprc^tm1Mak Tg(TcraTcrb)425Cbn/0
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:158876 )

decreased CD4-positive, alpha-beta T cell number ( J:158876 )

• fewer Tg(TcraTcrb)425Cbn CD4+ T cells develop compared to in wild-type Tg(TcraTcrb)425Cbn mice

hematopoietic system

thymus hypoplasia ( J:158876 )

decreased CD4-positive, alpha-beta T cell number ( J:158876 )

• fewer Tg(TcraTcrb)425Cbn CD4+ T cells develop compared to in wild-type Tg(TcraTcrb)425Cbn mice

endocrine/exocrine glands

thymus hypoplasia ( J:158876 )

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