Phenotypes associated with this allele

• Allele Symbol: Hp^tm1Skl
• Allele Name: targeted mutation 1, Sai-Kiang Lim
• Allele ID: MGI:2181293
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hp^tm1Skl/Hp^tm1Skl	involves: 129P2/OlaHsd * C57BL/6J	MGI:3610195
cx2	Hp^tm1Skl/Hp^tm1Skl Hpx^tm1Altr/Hpx^tm1Altr	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J	MGI:3609566
cx3	Apc^Min/Apc^+ Hp^tm1Skl/Hp^tm1Skl	involves: 129P2/OlaHsd * C57BL/6J	MGI:3610196

Genotype
MGI:3610195

hm1

• Allelic Composition: Hp^tm1Skl/Hp^tm1Skl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:49888 )

• increased susceptibility to lethal effects of phenylhydrazine induced acute hemolysis

postnatal lethality, incomplete penetrance ( J:49888 )

• number of homozygotes fewer than expected at weaning

homeostasis/metabolism

hemoglobinemia ( J:49888 )

• although hemoglobin levels are normal, clearance of plasma hemoglobin is slowed

increased kidney iron level ( J:97082 )

• iron content of kidneys is significantly elevated at 3 months of age

• ischemic injury also results in an abnormally high increase in iron in kidneys

increased susceptibility to xenobiotic induced morbidity/mortality ( J:49888 )

• increased susceptibility to lethal effects of phenylhydrazine induced acute hemolysis

renal/urinary system

increased kidney iron level ( J:97082 )

• iron content of kidneys is significantly elevated at 3 months of age

• ischemic injury also results in an abnormally high increase in iron in kidneys

abnormal renal tubule morphology ( J:49888 , J:97082 )

• heavier than normal deposition of hemoglobin and appearance of cytoplasmic vacuoles after induced acute hemolysis (J:49888)

• hemoglobin accumulation in kidneys greater than seen in liver and spleen (J:97082)

abnormal kidney physiology ( J:49888 )

• increased lipid peroxidation in kidneys of survivors of induced acute hemolysis

Genotype
MGI:3609566

cx2

• Allelic Composition: Hp^tm1Skl/Hp^tm1Skl; Hpx^tm1Altr/Hpx^tm1Altr
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:80539 )

• reduced susceptibility to lethal hemolytic stress resulting from administration of phenylhydrazine

homeostasis/metabolism

abnormal blood homeostasis ( J:80539 )

• recovery of blood chemistry parameters after induced acute hemolysis, almost complete by 7 days

abnormal circulating protein level ( J:80539 )

• heme oxygenase levels not elevated as much as normal as a result of induced acute hemolysis

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:80539 )

• reduced susceptibility to lethal hemolytic stress resulting from administration of phenylhydrazine

liver/biliary system

liver inflammation ( J:80539 )

• increased kupffer cell accumulation of hemoglobin 1 day after induced acute hemolysis

• pronounced inflammation after 7 days

• splenectomy also leads to liver inflammation

immune system

enlarged spleen ( J:80539 )

• after induced acute hemolysis

increased spleen red pulp amount ( J:80539 )

• enlarged spleen largely due to increased red pulp, accumulation of red blood cells

liver inflammation ( J:80539 )

• increased kupffer cell accumulation of hemoglobin 1 day after induced acute hemolysis

• pronounced inflammation after 7 days

• splenectomy also leads to liver inflammation

hematopoietic system

enlarged spleen ( J:80539 )

• after induced acute hemolysis

increased spleen red pulp amount ( J:80539 )

• enlarged spleen largely due to increased red pulp, accumulation of red blood cells

growth/size/body

enlarged spleen ( J:80539 )

• after induced acute hemolysis

Genotype
MGI:3610196

cx3

• Allelic Composition: Apc^Min/Apc⁺; Hp^tm1Skl/Hp^tm1Skl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

neoplasm

increased gastrointestinal tumor incidence ( J:75249 )

• intestinal tumor burden at 60-65 days of age increased by 2-3 fold

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:75249 )

• intestinal tumor burden at 60-65 days of age increased by 2-3 fold