All Phenotypes Ppp3cb<tm1Jmk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ppp3cb^tm1Jmk
targeted mutation 1, Jeffery D Molkentin
MGI:2181294

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk	involves: 129S6/SvEvTac	MGI:3652921
hm2	Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk	involves: 129S6/SvEvTac * C57BL/6	MGI:3041075
cx3	Rcan1^tm1Jmol/Rcan1^tm1Jmol Rcan2^tm1Jmol/Rcan2^tm1Jmol Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk	involves: 129S6/SvEvTac * C57BL/6	MGI:3652928
cx4	Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk Tg(Myh6-Mapk14*)1Jmol/0	involves: 129S6/SvEvTac * C57BL/6 * FVB	MGI:3851717
cx5	Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0 Tg(Myh6-tTA)55Rbns/0	involves: 129S6/SvEvTac * FVB	MGI:5897404

Allelic Composition	Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cb^tm1Jmk mutation (1 available); any Ppp3cb mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:109586 )

• in response to stimulation, total splenocytes show reduced proliferation

abnormal cytokine secretion ( J:109586 )

• in response to stimulation, total splenocytes show increased Il2 production compared to wild-type

homeostasis/metabolism

decreased susceptibility to injury ( J:109586 )

• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated

muscle

decreased skeletal muscle fiber diameter ( J:110822 )

• the cross-sectional area of the soleus is decreased

• the cross-sectional area in the extensor digitorum longus is normal

increased skeletal muscle fiber number ( J:110822 )

• the number of fibers is increased in the soleus

• the fiber number in the extensor digitorum longus is normal

abnormal skeletal muscle fiber type ratio ( J:110822 )

• the skeletal muscle exhibits less oxidative/slow fiber muscle type than wild-type

growth/size/body

decreased body weight ( J:110822 )

• mice exhibit reduced body weight despite normal muscle weights for their size (27.0+/-1.0 g compared to 30.3+/-0.7 g in wild-type mice)

hematopoietic system

decreased T cell proliferation ( J:109586 )

• in response to stimulation, total splenocytes show reduced proliferation

cellular

decreased T cell proliferation ( J:109586 )

• in response to stimulation, total splenocytes show reduced proliferation

Allelic Composition	Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cb^tm1Jmk mutation (1 available); any Ppp3cb mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cardiac histological analysis of wild type and Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk mice

cardiovascular system

cardiovascular system phenotype ( J:75775 )

N	• normal cardiovascular function • normal fractional shortening • normal heart rate • normal mean arterial blood pressure • normal angiotensin II-induced pressor response

small heart ( J:75775 )

• 12% reduction in basal heart size, with trend toward smaller chamber dimensions, ventricular wall thickness, and septal wall thickness

decreased response of heart to induced stress ( J:75775 )

• inability to mount hypertrophic response to pressure overload, angiotensin II infusion, or isoproterenol infusion

growth/size/body

decreased body weight ( J:75775 )

• male mice showed 10% reduction in body weight at 8 weeks of age

hematopoietic system

decreased T cell proliferation ( J:77729 )

• in response to either CD3-activating antibodies or PMA/ionomycin

decreased thymus weight ( J:75775 )

thymus hypoplasia ( J:77729 )

• evident between 4 and 8 weeks of age

abnormal T cell differentiation ( J:77729 )

decreased T cell number ( J:77729 )

• of total peripheral T cells

decreased single-positive T cell number ( J:77729 )

• reduced numbers of CD3+, and CD4 and CD8 single positive T cells

immune system

decreased T cell proliferation ( J:77729 )

• in response to either CD3-activating antibodies or PMA/ionomycin

decreased thymus weight ( J:75775 )

thymus hypoplasia ( J:77729 )

• evident between 4 and 8 weeks of age

abnormal T cell differentiation ( J:77729 )

decreased T cell number ( J:77729 )

• of total peripheral T cells

decreased single-positive T cell number ( J:77729 )

• reduced numbers of CD3+, and CD4 and CD8 single positive T cells

homeostasis/metabolism

decreased response of heart to induced stress ( J:75775 )

• inability to mount hypertrophic response to pressure overload, angiotensin II infusion, or isoproterenol infusion

endocrine/exocrine glands

decreased thymus weight ( J:75775 )

thymus hypoplasia ( J:77729 )

• evident between 4 and 8 weeks of age

cellular

decreased T cell proliferation ( J:77729 )

• in response to either CD3-activating antibodies or PMA/ionomycin

Allelic Composition	Rcan1^tm1Jmol/Rcan1^tm1Jmol Rcan2^tm1Jmol/Rcan2^tm1Jmol Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cb^tm1Jmk mutation (1 available); any Ppp3cb mutation (67 available)
Rcan1^tm1Jmol mutation (1 available); any Rcan1 mutation (26 available)
Rcan2^tm1Jmol mutation (1 available); any Rcan2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:109586 )

• mice show a significant increase in cumulative activity during light and dark conditions, even greater than that shown in Dscr1/Dscr1l1 knockouts

immune system

decreased T cell proliferation ( J:109586 )

• in response to stimulation, total splenocytes show reduced proliferation

abnormal CD4-positive, alpha beta T cell morphology ( J:109586 )

• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed

abnormal CD8-positive, alpha beta T cell morphology ( J:109586 )

• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed

abnormal CD4-positive, alpha-beta T cell physiology ( J:109586 )

• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed

abnormal cytokine secretion ( J:109586 )

• in response to stimulation, total splenocytes show increased Il2 production compared to wild-type

hematopoietic system

decreased T cell proliferation ( J:109586 )

• in response to stimulation, total splenocytes show reduced proliferation

abnormal CD4-positive, alpha beta T cell morphology ( J:109586 )

• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed

abnormal CD8-positive, alpha beta T cell morphology ( J:109586 )

• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed

abnormal CD4-positive, alpha-beta T cell physiology ( J:109586 )

• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed

cardiovascular system

decreased response of heart to induced stress ( J:109586 )

• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated

homeostasis/metabolism

decreased response of heart to induced stress ( J:109586 )

• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated

cellular

decreased T cell proliferation ( J:109586 )

• in response to stimulation, total splenocytes show reduced proliferation

Allelic Composition	Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk Tg(Myh6-Mapk14*)1Jmol/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cb^tm1Jmk mutation (1 available); any Ppp3cb mutation (67 available)
Tg(Myh6-Mapk14*)1Jmol mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:83547 )

N	• at 2 months, mice show complete rescue in hypertrophic growth seen in Tg(Myh6-Mapk14)1Jmol animals • rescue of the chamber enlargement and reduced fractional shortening is also observed • interstitial cell fibrosis is significantly attenuated compare with Tg(Myh6-Mapk14)1Jmol mice

Allelic Composition	Ppp3cb^tm1Jmk/Ppp3cb^tm1Jmk Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0 Tg(Myh6-tTA)55Rbns/0
Genetic Background	involves: 129S6/SvEvTac * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cb^tm1Jmk mutation (1 available); any Ppp3cb mutation (67 available)
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

thin interventricular septum ( J:234490 )

• as in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

increased heart weight ( J:234490 )

• less than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

increased heart left ventricle size ( J:234490 )

• as in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

decreased cardiac muscle contractility ( J:234490 )

• more so than in Ppp3cb^tm1Jmk homozygotes and similar to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

muscle

decreased cardiac muscle contractility ( J:234490 )

• more so than in Ppp3cb^tm1Jmk homozygotes and similar to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

growth/size/body

increased heart weight ( J:234490 )

• less than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

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