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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgaltm1Mak
targeted mutation 1, Tak W Mak
MGI:2181378
Summary 3 genotypes


Genotype
MGI:3722098
hm1
Allelic
Composition		 Itgaltm1Mak/Itgaltm1Mak
Genetic
Background		 B6.129P2-Itgaltm1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Mak mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:110889 )
• reduced IL-2-activated NK cytotoxicity against tumor cell lines
• impaired binding (conjugate formation) to target cells
• normal lymphocyte development and normal numbers of leukocyte subpopulations
• normal IL-2-activated NK cell differentiation and activation
increased circulating interleukin-10 level ( J:123460 )
• serum levels of IL-10 are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
increased circulating interleukin-2 level ( J:123460 )
• serum levels of IL-2 are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
increased circulating tumor necrosis factor level ( J:123460 )
• serum levels of TNF-alpha levels are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
decreased susceptibility to endotoxin shock ( J:123460 )
• mice are resistant to death induced by up to 1000 times the normally lethal dose of LPS
• mice fail to exhibit liver injury in response to low doses of LPS with only marginal signs of apoptosis at 8 hours compared to wild-type mice that exhibit hepatocyte destruction at 6 hours
• TNF-alpha, IL-2 and IL-10 levels are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
• following treatment with a lose dose of LPS, platelet levels fail to increase as much as in heterozygous mice

homeostasis/metabolism
increased circulating interleukin-10 level ( J:123460 )
• serum levels of IL-10 are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
increased circulating interleukin-2 level ( J:123460 )
• serum levels of IL-2 are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
increased circulating tumor necrosis factor level ( J:123460 )
• serum levels of TNF-alpha levels are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells

hematopoietic system
thrombocytopenia ( J:123460 )
• following treatment with a lose dose of LPS, platelet levels fail to increase as much as in heterozygous mice
impaired natural killer cell mediated cytotoxicity ( J:110889 )
• reduced IL-2-activated NK cytotoxicity against tumor cell lines
• impaired binding (conjugate formation) to target cells
• normal lymphocyte development and normal numbers of leukocyte subpopulations
• normal IL-2-activated NK cell differentiation and activation




Genotype
MGI:3722099
ht2
Allelic
Composition		 Itgaltm1Mak/Itgal+
Genetic
Background		 B6.129P2-Itgaltm1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Mak mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to endotoxin shock ( J:123460 )
• following treatment with a lethal dose of LPS, mice succumb after 10 hours compared to wild-type mice that succumb after 8 hours
• mice exhibit a delay in the onset of liver injury in response to low doses of LPS with injury levels at 8 hours comparable to those seen at 6 hours in wild-type mice




Genotype
MGI:4942402
cx3
Allelic
Composition		 Cd44tm1Mak/Cd44tm1Mak
Itgaltm1Mak/Itgaltm1Mak
Genetic
Background		 B6.129P2-Cd44tm1Mak Itgaltm1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44tm1Mak mutation (1 available); any Cd44 mutation (72 available)
Itgaltm1Mak mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:110889 )
• further reduced IL-2-activated NK cytotoxicity against tumor cell lines than that of the single mutation mice
• further impaired binding (conjugate formation) to target cells than that of the single mutation mice
• normal lymphocyte development and normal numbers of leukocyte subpopulations
• normal IL-2-activated NK cell differentiation and activation

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:110889 )
• further reduced IL-2-activated NK cytotoxicity against tumor cell lines than that of the single mutation mice
• further impaired binding (conjugate formation) to target cells than that of the single mutation mice
• normal lymphocyte development and normal numbers of leukocyte subpopulations
• normal IL-2-activated NK cell differentiation and activation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory