About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgaltm1Mak
targeted mutation 1, Tak W Mak
MGI:2181378
Summary 3 genotypes


Genotype
MGI:3722098
hm1
Allelic
Composition		 Itgaltm1Mak/Itgaltm1Mak
Genetic
Background		 B6.129P2-Itgaltm1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Mak mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:110889 )
• reduced IL-2-activated NK cytotoxicity against tumor cell lines
• impaired binding (conjugate formation) to target cells
• normal lymphocyte development and normal numbers of leukocyte subpopulations
• normal IL-2-activated NK cell differentiation and activation
increased circulating interleukin-10 level ( J:123460 )
• serum levels of IL-10 are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
increased circulating interleukin-2 level ( J:123460 )
• serum levels of IL-2 are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
increased circulating tumor necrosis factor level ( J:123460 )
• serum levels of TNF-alpha levels are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
decreased susceptibility to endotoxin shock ( J:123460 )
• mice are resistant to death induced by up to 1000 times the normally lethal dose of LPS
• mice fail to exhibit liver injury in response to low doses of LPS with only marginal signs of apoptosis at 8 hours compared to wild-type mice that exhibit hepatocyte destruction at 6 hours
• TNF-alpha, IL-2 and IL-10 levels are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
• following treatment with a lose dose of LPS, platelet levels fail to increase as much as in heterozygous mice

homeostasis/metabolism
increased circulating interleukin-10 level ( J:123460 )
• serum levels of IL-10 are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
increased circulating interleukin-2 level ( J:123460 )
• serum levels of IL-2 are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells
increased circulating tumor necrosis factor level ( J:123460 )
• serum levels of TNF-alpha levels are elevated following a low dose LPS challenge compared to similarly treated wild-type mice due to an increase in cytokine producing cells

hematopoietic system
thrombocytopenia ( J:123460 )
• following treatment with a lose dose of LPS, platelet levels fail to increase as much as in heterozygous mice
impaired natural killer cell mediated cytotoxicity ( J:110889 )
• reduced IL-2-activated NK cytotoxicity against tumor cell lines
• impaired binding (conjugate formation) to target cells
• normal lymphocyte development and normal numbers of leukocyte subpopulations
• normal IL-2-activated NK cell differentiation and activation




Genotype
MGI:3722099
ht2
Allelic
Composition		 Itgaltm1Mak/Itgal+
Genetic
Background		 B6.129P2-Itgaltm1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Mak mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to endotoxin shock ( J:123460 )
• following treatment with a lethal dose of LPS, mice succumb after 10 hours compared to wild-type mice that succumb after 8 hours
• mice exhibit a delay in the onset of liver injury in response to low doses of LPS with injury levels at 8 hours comparable to those seen at 6 hours in wild-type mice




Genotype
MGI:4942402
cx3
Allelic
Composition		 Cd44tm1Mak/Cd44tm1Mak
Itgaltm1Mak/Itgaltm1Mak
Genetic
Background		 B6.129P2-Cd44tm1Mak Itgaltm1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44tm1Mak mutation (1 available); any Cd44 mutation (72 available)
Itgaltm1Mak mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:110889 )
• further reduced IL-2-activated NK cytotoxicity against tumor cell lines than that of the single mutation mice
• further impaired binding (conjugate formation) to target cells than that of the single mutation mice
• normal lymphocyte development and normal numbers of leukocyte subpopulations
• normal IL-2-activated NK cell differentiation and activation

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:110889 )
• further reduced IL-2-activated NK cytotoxicity against tumor cell lines than that of the single mutation mice
• further impaired binding (conjugate formation) to target cells than that of the single mutation mice
• normal lymphocyte development and normal numbers of leukocyte subpopulations
• normal IL-2-activated NK cell differentiation and activation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory