All Phenotypes Hfe<tm1Sly> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hfe^tm1Sly
targeted mutation 1, William S Sly
MGI:2181388

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hfe^tm1Sly/Hfe^tm1Sly	Not Specified	MGI:3033464
ht2	Hfe^tm1Sly/Hfe^tm2Sly	involves: 129X1/SvJ * C57BL/6J	MGI:3033465
cx3	Cp^m1Cbea/Cp^m1Cbea Hfe^tm1Sly/Hfe^tm1Sly	involves: C3H/DiSnA * C57BL/10ScSnA	MGI:3715153

Allelic Composition	Hfe^tm1Sly/Hfe^tm1Sly
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm1Sly mutation (0 available); any Hfe mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased liver iron level ( J:88143 )

• increased in both males and females

liver/biliary system

increased liver iron level ( J:88143 )

• increased in both males and females

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemochromatosis type 1		DOID:0111029	OMIM:235200	J:88143

Allelic Composition	Hfe^tm1Sly/Hfe^tm2Sly
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm1Sly mutation (0 available); any Hfe mutation (35 available)
Hfe^tm2Sly mutation (0 available); any Hfe mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased liver iron level ( J:88143 )

• intermediate hepatic iron concentrations

• higher than that of wild-type mice, but lower than that of Hfe^tm1Sly homozygotes

liver/biliary system

increased liver iron level ( J:88143 )

• intermediate hepatic iron concentrations

• higher than that of wild-type mice, but lower than that of Hfe^tm1Sly homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemochromatosis type 1		DOID:0111029	OMIM:235200	J:88143

Allelic Composition	Cp^m1Cbea/Cp^m1Cbea Hfe^tm1Sly/Hfe^tm1Sly
Genetic Background	involves: C3H/DiSnA * C57BL/10ScSnA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cp^m1Cbea mutation (0 available); any Cp mutation (76 available)
Hfe^tm1Sly mutation (0 available); any Hfe mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hemochromatosis ( J:122133 )

• increased liver non-heme iron content

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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