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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cremtm1Gsc
targeted mutation 1, Gunther Schutz
MGI:2181391
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cremtm1Gsc/Cremtm1Gsc involves: 129 * C57BL/6 MGI:2181410
cn2
 		Creb1tm3Gsc/Creb1tm3Gsc
Cremtm1Gsc/Cremtm1Gsc
Tg(Dbh-icre)1Gsc/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:4355664
cn3
 		Creb1tm3Gsc/Creb1tm3Gsc
Cremtm1Gsc/Cremtm1Gsc
Tg(Camk2a-cre)1Gsc/0 		involves: 129P2/OlaHsd * FVB/N MGI:4843915
cx4
 		Creb1tm3.1Gsc/Creb1tm3.1Gsc
Cremtm1Gsc/Cremtm1Gsc 		involves: 129P2/OlaHsd * C57BL/6 MGI:4999629


Genotype
MGI:2181410
hm1
Allelic
Composition		 Cremtm1Gsc/Cremtm1Gsc
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cremtm1Gsc mutation (0 available); any Crem mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased heart left ventricle muscle contractility ( J:81241 )
• depressed left ventricular contractile function and impaired relaxation in the absence of cardiac hypertrophy or increased mortality are seen in homozygotes

reproductive system
arrest of male meiosis ( J:31889 )
• no spermatids beyond step 4 or rarely step 5 of spermatogenesis are seen in homozygotes
small testis ( J:31889 )
• adult testes are smaller in size and weight in mutants compared to wild-type littermates
male infertility ( J:31889 )
• males are completely sterile

muscle
decreased heart left ventricle muscle contractility ( J:81241 )
• depressed left ventricular contractile function and impaired relaxation in the absence of cardiac hypertrophy or increased mortality are seen in homozygotes

endocrine/exocrine glands
small testis ( J:31889 )
• adult testes are smaller in size and weight in mutants compared to wild-type littermates

cellular
arrest of male meiosis ( J:31889 )
• no spermatids beyond step 4 or rarely step 5 of spermatogenesis are seen in homozygotes




Genotype
MGI:4355664
cn2
Allelic
Composition		 Creb1tm3Gsc/Creb1tm3Gsc
Cremtm1Gsc/Cremtm1Gsc
Tg(Dbh-icre)1Gsc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1tm3Gsc mutation (2 available); any Creb1 mutation (61 available)
Cremtm1Gsc mutation (0 available); any Crem mutation (40 available)
Tg(Dbh-icre)1Gsc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:121244 )
N
• mice survive birth and do not show reduced lifespans unlike lethality observed in Creb1-germline null mice

nervous system
decreased neuron apoptosis ( J:121244 )
• at E17.5 reduced numbers of apoptotic cells are observed compared to controls Creb1tm1Gsc null mice
abnormal superior cervical ganglion morphology ( J:121244 )
• numbere of SCG neurons is increased compared to controls at E17.5

cellular
decreased neuron apoptosis ( J:121244 )
• at E17.5 reduced numbers of apoptotic cells are observed compared to controls Creb1tm1Gsc null mice




Genotype
MGI:4843915
cn3
Allelic
Composition		 Creb1tm3Gsc/Creb1tm3Gsc
Cremtm1Gsc/Cremtm1Gsc
Tg(Camk2a-cre)1Gsc/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1tm3Gsc mutation (2 available); any Creb1 mutation (61 available)
Cremtm1Gsc mutation (0 available); any Crem mutation (40 available)
Tg(Camk2a-cre)1Gsc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:142518 )
N
• mutants exhibit a normal response to cocaine, even though cocaine-induced transcription is blunted




Genotype
MGI:4999629
cx4
Allelic
Composition		 Creb1tm3.1Gsc/Creb1tm3.1Gsc
Cremtm1Gsc/Cremtm1Gsc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1tm3.1Gsc mutation (0 available); any Creb1 mutation (61 available)
Cremtm1Gsc mutation (0 available); any Crem mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal lung development ( J:171712 )
• lung phenotype does not differ from that of mice homozygous for Creb1tm3.1Gsc alone




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory