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Allele Symbol Allele Name Allele ID |
Creb1tm3Gsc targeted mutation 3, Gunther Schutz MGI:2181395 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• number of caspase 3-positive (apoptotic) cells is decreased compared to controls in the SCG at E17.5
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• number of caspase 3-positive (apoptotic) cells is decreased compared to controls in the SCG at E17.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• phenotype is indistinguishable from mice homozygous null for Lrp5
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• decreased bone formation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• loss of expression of 1 copy of Creb1 in osteoblasts rescues the bone phenotype seen in Htrb1 null mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice survive birth and do not show reduced lifespans unlike lethality observed in Creb1-germline null mice
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| N |
• no major alterations in size of the superior cervical ganglia (SCG) or in morphology of noradrenergic neurons are observed at E17.5; SCG and stellate ganglion are properly shaped and placed compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice survive birth and do not show reduced lifespans unlike lethality observed in Creb1-germline null mice
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• at E17.5 reduced numbers of apoptotic cells are observed compared to controls Creb1tm1Gsc null mice
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• numbere of SCG neurons is increased compared to controls at E17.5
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• at E17.5 reduced numbers of apoptotic cells are observed compared to controls Creb1tm1Gsc null mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal glucose and insulin homeostasis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 weeks
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• at 12 weeks
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• at 12 weeks
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• at 12 weeks
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• at 12 weeks
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• at 12 weeks
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• at 12 weeks
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• at 12 weeks
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• at 12 weeks
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• at 12 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mutants exhibit a normal response to cocaine, even though cocaine-induced transcription is blunted
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/02/2024 MGI 6.13 |
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