Analysis Tools
mortality/aging
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• mice continue to die through E16.5 when only 1 is recovered
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• mice exhibit embryonic lethality beginning at E12
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hematopoietic system
| N |
• despite disruptions in embryonic erythropoiesis, adult hematopoiesis is normal in irradiated mice reconstituted with Socs3tm1Jni cells
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• embryos exhibit a shift from more immature populations to more mature, non-proliferative populations of erythroid cells
• in a colony-forming assay, the number of erythroid colony-forming cells, burst-forming cells and IL-3 sensitive multilineage progenitors is decreased 10-fold compared to wild-type while colony size is typically 5 to 10 times larger than colonies from wild type mice
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• at E12.5, mice exhibit erythrocytosis that increases in frequency with age
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• most erythrocytes are still nucleated unlike in wild-type mice
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liver/biliary system
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• at E12.5, the fetal liver is distorted with an excess of erythroid cells
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embryo
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• embryos exhibit a shift from more immature populations to more mature, non-proliferative populations of erythroid cells
• in a colony-forming assay, the number of erythroid colony-forming cells, burst-forming cells and IL-3 sensitive multilineage progenitors is decreased 10-fold compared to wild-type while colony size is typically 5 to 10 times larger than colonies from wild type mice
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growth/size/body
integument
reddish skin
(
J:57476
)
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• mice exhibit erythmia throughout the embryo including the head and lens of the eye
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