Analysis Tools
pigmentation
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• 3 out of 4 homozygotes were albino
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vision/eye
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• after being kept in constant light for more than 20 days less loss of photoreceptors occurred than in albino controls
• after 60 days in constant light the number of nuclei in the outer nuclear layer was reduced but still more than 4X that of albino controls
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• did not occur in albino mice maintained in a normal light cycle unlike albino controls
• photoreceptor nuclei in the outer nuclear layer remainder normal unlike albino controls where the number is reduced
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• regeneration of bleached rhodopsin required 18-24 hours as opposed to a more normal 1.5 hours
• little restoration of dark adaptation occurred in the 3 hours which was adequate for control mice
• cone recovery after bleaching was delayed by a factor of 2 relative to controls
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nervous system
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• after being kept in constant light for more than 20 days less loss of photoreceptors occurred than in albino controls
• after 60 days in constant light the number of nuclei in the outer nuclear layer was reduced but still more than 4X that of albino controls
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integument
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• 3 out of 4 homozygotes were albino
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Bothnia retinal dystrophy | DOID:0050683 |
OMIM:607475 |
J:68444 | |
