All Phenotypes Jchain<tm1Jse> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jchain^tm1Jse/Jchain^tm1Jse	C.129X1-Jchain^tm1Jse	MGI:4353908
hm2	Jchain^tm1Jse/Jchain^tm1Jse	involves: 129X1/SvJ	MGI:4353906

Allelic Composition	Jchain^tm1Jse/Jchain^tm1Jse
Genetic Background	C.129X1-Jchain^tm1Jse

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jchain^tm1Jse mutation (0 available); any Jchain mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:62298 )

• mutant mice have a higher survival rate of 58% compared to 35% in wild-type controls following infection with genital herpes simplex type 2

immune system

increased susceptibility to parasitic infection ( J:140515 )

• mice are more susceptible to Giardia muris infection compared to controls

• seven weeks after infection, mice have over 1,000-fold higher trophozoite numbers in the small intestine compared with controls

decreased susceptibility to Herpesvirales infection ( J:62298 )

• mice are less susceptible to genital herpes simplex type 2 infection

• mice exhibit fewer severe vaginal symptoms following HSV-2 genital infection, with 27 of 31 WT mice developing a vaginal symptom score of 2 or greater compared with 18 of 31 mutant mice

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:62298 )

• mutant mice have a higher survival rate of 58% compared to 35% in wild-type controls following infection with genital herpes simplex type 2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal bile composition ( J:75843 )

• IgA levels in the bile are 3.5-fold lower than in controls

• the IgA present in the bile is mostly in a monomer state compared to the dimeric state that predominates in wild-type bile

immune system

abnormal B cell physiology ( J:75843 )

• production of dimeric IgA is severely curtailed in these mice

increased IgA level ( J:34042 , J:75843 )

• serum IgA levels are about 35-fold higher (J:34042)

• IgA levels found in bronchoalveolar lavage fluid are 8- to 18- fold higher than in controls (J:34042)

• IgA is often in monomeric form in the serum and mucosal fluids (J:34042)

• IgA levels in mucosal secretions and breast milk are not significantly different from controls (J:34042)

• serum IgA levels are over 30-fold higher than in controls (J:75843)

• monomer to dimer is 10:1 ratio compared to 1:1 in wild-type (J:75843)

digestive/alimentary system

abnormal intestinal secretion ( J:34042 , J:75843 )

• while levels of IgA are normal in intestinal fluids, monomeric forms of IgA are found in these fluids that are not found in wild-type controls (J:34042)

• fecal levels of IgA are 5.5-fold lower than in controls (J:75843)

endocrine/exocrine glands

abnormal milk composition ( J:34042 )

• monomeric forms of IgA are found in the breast milk while the dimeric form of IgA predominates in wild-type breast milk

integument