Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nodaltm2Rob targeted mutation 2, Elizabeth J Robertson MGI:2181583 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• axial mesendoderm does not develop
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• embryos show a spectrum of defects, ranging from no phenotype through a moderate anterior truncation in which some of the midbrain is retain to a severe anterior truncation in which all forebrain and midbrain tissue is absent
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice die by 6 weeks of age
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• 30% of mice survive to birth
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• at E9.5, the heart loops ventrally instead of laterally as in wild-type mice
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• at E11.5, heart apex is ambiguously positioned unlike in wild-type mice
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• at E9.0, the heart is positioned more ventrally than normal
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• mutant embryos have 4 right lobes and 2 or 3 left lobes, indicating partial right pulmonary isomerism
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| N |
• mice exhibit normal gastrulation
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• mice are runted
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• partial
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• mutant embryos have 4 right lobes and 2 or 3 left lobes, indicating partial right pulmonary isomerism
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in some mice
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• severely affected mice exhibit a decrease in midline tissue compared with wild-type mice due to abnormal gastrulation movements
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• at E8.5, mice exhibit a reduction in anterior neural tissues compared with wild-type mice
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• in some mice
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• in some mice
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• fused somites
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• constriction at the boundary in 40% of mice at E6.5
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• at E6.5, 40% of embryos are abnormal with thickened patch of visceral endoderm characteristic of the anterior visceral endoderm
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• in some mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• axial mesendoderm loss
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• 38% of embryos present with moderate or severe anterior truncation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 100% of embryos present with moderate or severe anterior truncation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 72% of embryos present with moderate to severe anterior truncation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at E6.25 decrease in Nodal expression rescues patterning defects in the anterior visceral endoderm, extraembryonic ectoderm and mesoderm and the decrease in embryo size that are seen in Trim33 single homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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