All Phenotypes P2rx1<tm1Chn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

P2rx1^tm1Chn
targeted mutation 1, R Channel
MGI:2181608

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	P2rx1^tm1Chn/P2rx1^tm1Chn	involves: 129P2/OlaHsd * MF1	MGI:2662555

Allelic Composition	P2rx1^tm1Chn/P2rx1^tm1Chn
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx1^tm1Chn mutation (0 available); any P2rx1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

hypertension ( J:59336 )

• slight increase in systolic blood pressure at rest

reproductive system

azoospermia ( J:59336 )

• sperm was undetected in uterine lavage after matings with mutant males

• abundant motile sperm were detected in the vas deferens and epididymis

abnormal vas deferens morphology ( J:59336 )

• impaired neurogenic vas deferens contraction

decreased litter size ( J:59336 )

• mean litter size reduced by 30%

male infertility ( J:59336 )

• fertility reduced by ~90%

cellular

azoospermia ( J:59336 )

• sperm was undetected in uterine lavage after matings with mutant males

• abundant motile sperm were detected in the vas deferens and epididymis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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