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Allele Symbol Allele Name Allele ID |
Lipetm1Ishi targeted mutation 1, Shun Ishibashi MGI:2181610 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in male mice
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• in male mice
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• following exposure to acLDL, intracellular cholesterol ester levels in macrophages are increased 51% compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Lipetm1Ishi/Lipetm1Ishi males exhibit oligospermia and seminiferous tubule defects
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• testes lack neutral cholesterol ester hydrolase activities and contain 2.3-fold increase in cholesterol ester content
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• thickness of the epithelial layers of seminiferous tubules is reduced from 12 to 5-7 layers
• extensive vacuolation is observed in the epithelial cells
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• cellular hypertrophy of brown adipose tissue, with a 1.65-fold enlargement of brown adipose tissue
• median cytoplasmic area of brown adipose tissue adipoctyes is increased by about 5-fold
• triacylglycerol content is increased in brown adipose tissue
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• enlarged brown (5-fold) and white (2-fold) adipocytes
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• cellular hypertrophy of white adipose tissue, but to a lesser extent than seen in brown adipose tissue, with median cytoplasmic area enlarged by 2-fold
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• WAT expresses 40% lower activities of triacylglycerol lipase in the presence of 1 M NaCl (to selectively inhibit lipoprotein lipase)
• adipocytes isolated from WAT release reduced amounts of glycerol and free fatty acids into the incubation media
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• testes lack neutral cholesterol ester hydrolase activities and contain 2.3-fold increase in cholesterol ester content
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• thickness of the epithelial layers of seminiferous tubules is reduced from 12 to 5-7 layers
• extensive vacuolation is observed in the epithelial cells
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• triacylglycerol content is increased in brown adipose tissue
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• testes, brown adipose tissue, and white adipose tissue completely lack neutral cholesterol ester hydrolase activities
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| N |
• despite adipocyte abnormalities, mutants are not obese
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in male mice
|
|
• in male mice
|
|
• following exposure to acLDL, intracellular cholesterol ester levels in macrophages are increased 70% compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• depending on the statistical method, the atherosclerotic lesion surface area is increased 1.2 -to 1.7-fold compared to in Ldlrtm1Her homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• depending on the statistical method, the atherosclerotic lesion surface area is increased 2.0- to 4.3-fold compared to in Ldlrtm1Her homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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