Analysis Tools|
Allele Symbol Allele Name Allele ID |
Igf2rtm1Stw targeted mutation 1, Colin L Stewart MGI:2181634 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when this allele is inherited maternally, only 3.4% of mice from one breeding pair survived to adulthood
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• when this allele is inherited maternally, nearly all mice die within 12 hours of birth due to respiratory failure
• however, when this allele is inherited paternally mice exhibit normal survival and phenotype
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• in surviving mice when this allele is inherited maternally
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• when this allele is inherited maternally, surviving mice exhibit vulval closure
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• when this allele is inherited maternally, surviving mice exhibit reduced endometrium thickness compared to in wild-type mice
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• when this allele is inherited maternally, the uterus of mice that survive to adulthood is 7 times larger than in wild-type mice due to fluid accumulation secondary to an imperforate vagina
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• when this allele is inherited maternally, surviving mice exhibit imperforate vagina
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• two viable females recovered with a maternally inherited allele were infertile
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• of the two viable males recovered one was infertile while the other was fertile
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• when this allele is inherited maternally, mice exhibit myocardium hyperplasia
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• when this allele is inherited maternally, the tricuspid valve develops poorly
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• when this allele is inherited maternally, the intraventricular septum develops large, blood-filled sinusoids and reduced cell thickness to no more than 2 cells in diameter unlike in wild-type mice
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• when this allele is inherited maternally, heart size is 3 times larger than in wild-type mice at E19 and is enalrged in surviving mice
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• when this allele is inherited maternally
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• when this allele is inherited maternally
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• when this allele is inherited maternally, some mice have difficulty breathing
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• when this allele is inherited maternally, most mice fail to breath at birth
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| N |
• despite an increase in serum Igf2 levels, glucose serum levels are normal
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• when this allele is inherited maternally, Igf2 serum levels are increased compared to in wild-type mice
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• when this allele is inherited maternally, the weight of placenta and fetal membranes is increased 25% to 30% compared to in wild-type mice at E17 and continues to increase throughout the rest of the pregnancy unlike in wild-type mice
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• when this allele is inherited maternally, mice are unable to move effectively unlike wild-type mice
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• when this allele is inherited maternally
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• when this allele is inherited maternally, heart size is 3 times larger than in wild-type mice at E19 and is enalrged in surviving mice
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• when this allele is inherited maternally
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• when this allele is inherited maternally, mice are larger at birth with proportional increases in liver and lung weights
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• when this allele is inherited maternally
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• in surviving mice when this allele is inherited maternally
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• when this allele is inherited maternally, mice exhibit myocardium hyperplasia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2rtm1Stw and H19tm2Tilg are inherited maternally and Igf2tm1Rob is inherited paternally, mice die immediately after birth
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• when Igf2rtm1Stw and H19tm2Tilg are inherited maternally and Igf2tm1Rob is inherited paternally, mice exhibit postaxial polydactyly that is confined to a single forelimb
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• when Igf2rtm1Stw and H19tm2Tilg are inherited maternally and Igf2tm1Rob is inherited paternally, mice weigh 135% of wild-type
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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