All Phenotypes Slc12a2<tm1Bhk> MGI Mouse

behavior/neurological

absent startle reflex ( J:60671 )

• failure to startle in response to noise

ataxia ( J:60671 )

• ataxic gait that severely impaired performance on rotarod

head tossing ( J:60671 )

hyperactivity ( J:60671 )

unidirectional circling ( J:60671 )

• circling in a clockwise direction

reduced male mating frequency ( J:60671 )

• lower mating frequency putatively due to altered motor activity

reproductive system

decreased male germ cell number ( J:60671 )

• reduced number of spermatids

small testis ( J:60671 )

abnormal spermatogenesis ( J:60671 )

• however, seminiferous tubule formation is normal

azoospermia ( J:60671 )

• spermatozoa absent from the epididymis

abnormal spermatid morphology ( J:60671 )

• acrosomal granule defects observed in spermatids

reduced female fertility ( J:60671 )

• females are generally fertile, though they became pregnant less frequently than wild-type

• normal histology observed in the ovaries, oviducts, and uteri of females

male infertility ( J:60671 )

• however, normal seminiferous tubule formation was observed

growth/size/body

decreased body size ( J:60671 )

• size discrepancy relative to wild-type becomes less pronounced as mice reach maturity

decreased body weight ( J:60671 )

• 45% decrease in weight relative to wild-type at 14 days of age

postnatal growth retardation ( J:60671 )

hearing/vestibular/ear

abnormal hearing physiology ( J:60671 )

endocrine/exocrine glands