All Phenotypes Igf2r<tm1Arge> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igf2r^tm1Arge
targeted mutation 1, Argiris Efstratiadis
MGI:2181646

Summary

27 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129	MGI:3820224
hm2	Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820282
hm3	Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * C57BL/6J * MF1	MGI:3820212
ht4	Igf2r^tm1Arge/Igf2r⁺	involves: 129	MGI:3820222
ht5	Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820283
ht6	Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * C57BL/6J * MF1	MGI:3820209
ht7	Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * MF1	MGI:3820214
cx8	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820308
cx9	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820279
cx10	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820289
cx11	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820290
cx12	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820302
cx13	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820304
cx14	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820306
cx15	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820260
cx16	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820261
cx17	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820262
cx18	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820263
cx19	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820273
cx20	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820275
cx21	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820277
cx22	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820233
cx23	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129S/SvEv	MGI:3820234
cx24	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129S/SvEv	MGI:3820237
cx25	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820239
cx26	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820220
cx27	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820218

Allelic Composition	Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• most mice die around the time of birth but some survive

• Background Sensitivity: survival rate is dependent on strain background

perinatal lethality, incomplete penetrance ( J:34584 )

• most mice die around the time of birth but some survive

postnatal lethality, incomplete penetrance ( J:34584 )

• some mice die postnatally

reproductive system

abnormal uterus morphology ( J:34584 )

• 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina

enlarged uterus ( J:34584 )

• 10 of 16 surviving females exhibit a 6-fold increase in uterus size compared to in wild-type mice

vagina atresia ( J:34584 )

• 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina

reduced female fertility ( J:34584 )

• 2 of 3 females are infertile

reduced male fertility ( J:34584 )

• 1 of 6 males is infertile

cardiovascular system

thick interventricular septum ( J:34584 )

• the ventricular septum width is increased compared to in wild-type mice

enlarged heart ( J:34584 )

increased heart weight ( J:34584 )

• heart weight is 4-fold more than in wild-type mice

heart hyperplasia ( J:34584 )

increased heart left ventricle wall thickness ( J:34584 )

• mice exhibit a 38% increase in mural thickening of the left ventricle compared to in wild-type mice without hyperplasia

• mice exhibit a 4-fold larger wall volume compared to in wild-type mice

dilated heart left ventricle ( J:34584 )

• an 89% increase compared to in wild-type mice

dilated heart right ventricle ( J:34584 )

congestive heart failure ( J:34584 )

• perinatal lethality is likely caused by decompensated heart failure

homeostasis/metabolism

abnormal circulating hormone level ( J:34584 )

• IGF-II serum levels are 4.4-fold higher than in wild-type mice

edema ( J:34584 )

• mice are edematous at E17.5 and E18.5 unlike wild-type mice

growth/size/body

enlarged heart ( J:34584 )

increased heart weight ( J:34584 )

• heart weight is 4-fold more than in wild-type mice

heart hyperplasia ( J:34584 )

increased embryo size ( J:34584 )

• beginning at E13.5

increased birth body size ( J:34584 )

• mice are 35% to 40% larger than wild-type mice at birth

abnormal body water content ( J:34584 )

• water content at E17.5 and E18.5 is increased compared to in wild-type mice

increased fetal size ( J:34584 )

• mice are 35% to 40% larger than wild-type mice at E18.5

enlarged kidney ( J:34584 )

enlarged lung ( J:34584 )

pulmonary hyperplasia ( J:34584 )

enlarged liver ( J:34584 )

liver hyperplasia ( J:34584 )

limbs/digits/tail

polydactyly ( J:34584 )

• postaxial

kinked tail ( J:34584 )

embryo

increased embryo size ( J:34584 )

• beginning at E13.5

enlarged placenta ( J:34584 )

• beginning at E13.5

liver/biliary system

enlarged liver ( J:34584 )

liver hyperplasia ( J:34584 )

nervous system

increased brain size ( J:34584 )

renal/urinary system

enlarged kidney ( J:34584 )

hematopoietic system

increased nucleated erythrocyte cell number ( J:34584 )

• immature (nucleated) red blood cells persist in the embryonic circulation unlike in wild-type mice

respiratory system

enlarged lung ( J:34584 )

pulmonary hyperplasia ( J:34584 )

Allelic Composition	Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased birth weight ( J:34584 )

• birth weight is 140% of normal

Allelic Composition	Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * C57BL/6J * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• no mice survive the postnatal period

Allelic Composition	Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when this allele is inherited maternally, most mice die around the time of birth but some survive

• Background Sensitivity: survival rate is dependent on strain background

perinatal lethality, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, most mice die around the time of birth but some survive

• however, when this allele is inherited paternally no abnormal lethality is observed

postnatal lethality, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, some mice die postnatally

reproductive system

abnormal uterus morphology ( J:34584 )

• when this allele is inherited maternally, 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina

enlarged uterus ( J:34584 )

• when this allele is inherited maternally, 10 of 16 surviving females exhibit a 6-fold increase in uterus size compared to in wild-type mice

vagina atresia ( J:34584 )

• when this allele is inherited maternally, 10 of 16 surviving females exhibit distention of the uterus due to an imperforate vagina

reduced female fertility ( J:34584 )

• when this allele is inherited maternally, 2 of 3 females are infertile

reduced male fertility ( J:34584 )

• when this allele is inherited maternally, 1 of 6 males is infertile

cardiovascular system

thick interventricular septum ( J:34584 )

• when this allele is inherited maternally, the ventricular septum width is increased compared to in wild-type mice

enlarged heart ( J:34584 )

• when this allele is inherited maternally

increased heart weight ( J:34584 )

• when this allele is inherited maternally, heart weight is 4-fold more than in wild-type mice

heart hyperplasia ( J:34584 )

• when this allele is inherited maternally

increased heart left ventricle wall thickness ( J:34584 )

• when this allele is inherited maternally, mice exhibit a 38% increase in mural thickening of the left ventricle compared to in wild-type mice without hyperplasia

• when this allele is inherited maternally, mice exhibit a 4-fold larger wall volume compared to in wild-type mice

dilated heart left ventricle ( J:34584 )

• an 89% increase compared to in wild-type mice when this allele is inherited maternally

dilated heart right ventricle ( J:34584 )

• when this allele is inherited maternally

congestive heart failure ( J:34584 )

• when this allele is inherited maternally, perinatal lethality is likely caused by decompensated heart failure

homeostasis/metabolism

abnormal circulating hormone level ( J:34584 )

• when this allele is inherited maternally, IGF-II serum levels are 4.4-fold higher than in wild-type mice

edema ( J:34584 )

• when this allele is inherited maternally, mice are edematous at E17.5 and E18.5 unlike wild-type mice

growth/size/body

enlarged heart ( J:34584 )

• when this allele is inherited maternally

increased heart weight ( J:34584 )

• when this allele is inherited maternally, heart weight is 4-fold more than in wild-type mice

heart hyperplasia ( J:34584 )

• when this allele is inherited maternally

increased embryo size ( J:34584 )

• beginning at E13.5 when this allele is inherited maternally

increased birth body size ( J:34584 )

• when this allele is inherited maternally, mice are 35% to 40% larger than wild-type mice at birth

abnormal body water content ( J:34584 )

• when this allele is inherited maternally, water content at E17.5 and E18.5 is increased compared to in wild-type mice

increased fetal size ( J:34584 )

• when this allele is inherited maternally, mice are 35% to 40% larger than wild-type mice at E18.5

enlarged kidney ( J:34584 )

• when this allele is inherited maternally

enlarged lung ( J:34584 )

• when this allele is inherited maternally

pulmonary hyperplasia ( J:34584 )

• when this allele is inherited maternally

enlarged liver ( J:34584 )

• when this allele is inherited maternally

liver hyperplasia ( J:34584 )

• when this allele is inherited maternally

limbs/digits/tail

polydactyly ( J:34584 )

• postaxial when this allele is inherited maternally

kinked tail ( J:34584 )

• when this allele is inherited maternally

embryo

increased embryo size ( J:34584 )

• beginning at E13.5 when this allele is inherited maternally

enlarged placenta ( J:34584 )

• beginning at E13.5 when this allele is inherited maternally

liver/biliary system

enlarged liver ( J:34584 )

• when this allele is inherited maternally

liver hyperplasia ( J:34584 )

• when this allele is inherited maternally

nervous system

increased brain size ( J:34584 )

• when this allele is inherited maternally

renal/urinary system

enlarged kidney ( J:34584 )

• when this allele is inherited maternally

hematopoietic system

increased nucleated erythrocyte cell number ( J:34584 )

• when this allele is inherited maternally, immature (nucleated) red blood cells persist in the embryonic circulation unlike in wild-type mice

respiratory system

enlarged lung ( J:34584 )

• when this allele is inherited maternally

pulmonary hyperplasia ( J:34584 )

• when this allele is inherited maternally

Allelic Composition	Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * C57BL/6J * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• Background Sensitivity: when this allele is inherited maternally, 0.7% of mice survive the postnatal period compared to 16.2% on an 129/Sv MF1 background

lethality throughout fetal growth and development, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, some mice die between E17.5 and E18.5

postnatal lethality, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, 0.7% of mice survive the postnatal period compared to 16.2% on an 129/Sv MF1 background

Allelic Composition	Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• Background Sensitivity: when this allele is inherited maternally, 16.2% of mice survive beyond the postnatal period compared to 0.7% on a 129/Sv C57BL/6 MF1 background

postnatal lethality, incomplete penetrance ( J:34584 )

• Background Sensitivity: when this allele is inherited maternally, 16.2% of mice survive beyond the postnatal period compared to 0.7% on a 129/Sv C57BL/6 MF1 background

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)
M6pr^tm1Hlk mutation (0 available); any M6pr mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are fertile

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, birth weight is 61.5% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased birth weight ( J:34584 )

• birth weight is 109% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited paternally, birth weight is 45.9% of wild-type

increased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 109% of normal

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice die within 4 weeks of birth

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice exhibit a waddling gait

growth/size/body

decreased body size ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice are dwarfed

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice die within 4 weeks of birth

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are dwarfed

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice exhibit a waddling gait

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, mice are fertile

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, birth weight is 34.4% of normal

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 73.8% of normal

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2r^tm1Arge is inherited paternally, birth weight is 61.5% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 73.8% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• survival is normal

reproductive system

decreased litter size ( J:34584 )

• mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• birth weight is normal

slow postnatal weight gain ( J:34584 )

• mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, survival is normal

reproductive system

decreased litter size ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, birth weight is normal

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited paternally, birth weight is 47% of normal

slow postnatal weight gain ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• 3.7% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34584 )

• 3.7% of mice survive postnatally

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, 7.3% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, 7.3% of mice survive postnatally

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