Phenotypes associated with this allele

• Allele Symbol: Rom1^tm1Mci
• Allele Name: targeted mutation 1, Roderick R McInnes
• Allele ID: MGI:2181662
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rom1^tm1Mci/Rom1^tm1Mci	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3038629

Genotype
MGI:3038629

hm1

• Allelic Composition: Rom1^tm1Mci/Rom1^tm1Mci
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:61888 )

abnormal retina rod cell outer segment morphology ( J:61888 )

• rod outer segments are moderately disorganized at 1 month of age

• by 2 months of age there is a loss of parallel arrangement and gaps filled with amorphous material appear between outer segments

• there is a mixture of normal outer segments juxtaposed to others distorted with membranous whorls and large interdisk gaps

• rod outer segment organization improves somewhat after 4 months of age

• disks frequently have increased diameters; mean diameter is increased by 39%

• outer segment length is about 23% less than in control mice

• this is the result of a failure to increase in length between 1 and 2 months rather than progressive degeneration

retina rod cell degeneration ( J:61888 )

• rod photoreceptors apoptose although the rate of loss is slow

• the number of cone receptors is unchanged at 18 months of age

thin retina outer nuclear layer ( J:61888 )

• outer nuclear layer becomes progressively thinner after 2 months of age

abnormal rod electrophysiology ( J:61888 )

• maximal rod photoreceptor response is 50% lower at 9 months than in age matched controls

nervous system

abnormal retina rod cell outer segment morphology ( J:61888 )

• rod outer segments are moderately disorganized at 1 month of age

• by 2 months of age there is a loss of parallel arrangement and gaps filled with amorphous material appear between outer segments

• there is a mixture of normal outer segments juxtaposed to others distorted with membranous whorls and large interdisk gaps

• rod outer segment organization improves somewhat after 4 months of age

• disks frequently have increased diameters; mean diameter is increased by 39%

• outer segment length is about 23% less than in control mice

• this is the result of a failure to increase in length between 1 and 2 months rather than progressive degeneration

retina rod cell degeneration ( J:61888 )

• rod photoreceptors apoptose although the rate of loss is slow

• the number of cone receptors is unchanged at 18 months of age