Analysis Tools
mortality/aging
|
• mutants are born alive but die within a few hours of birth
|
growth/size/body
heterotaxia
(
J:79098
)
|
• positioning of stomach is randomized in mutants at birth whereas stomach is on the left side of abdominal cavity in wild-type
|
|
• mutants have 4 lung lobes on the right and 3 or 4 on the left
|
cardiovascular system
|
• at birth, apex of heart points to left, middle, or right of thoracic cavity instead of the left as in controls
|
|
• in embryos at 9.0 days, direction is randomized
|
|
• seen in most mutants at birth
|
|
• atrial septal defects are found in most mutants at birth
|
common atrium
(
J:79098
)
|
• major defect observed in all mutants is development of single common atrial chamber rather than separate left or right atria
|
respiratory system
|
• mutants have 4 lung lobes on the right and 3 or 4 on the left
|
hematopoietic system
small spleen
(
J:79098
)
|
• all compound heterozygotes have spleens that are reduced in size relative to controls
|
immune system
small spleen
(
J:79098
)
|
• all compound heterozygotes have spleens that are reduced in size relative to controls
|
