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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		P2ry1tm1Gac
targeted mutation 1, Christian Gachet
MGI:2181709
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		P2ry1tm1Gac/P2ry1tm1Gac involves: 129S2/SvPas * C57BL/6 MGI:3054528
ht2
 		P2ry1tm1Gac/P2ry1+ involves: 129S2/SvPas * C57BL/6 MGI:3054529


Genotype
MGI:3054528
hm1
Allelic
Composition		 P2ry1tm1Gac/P2ry1tm1Gac
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2ry1tm1Gac mutation (1 available); any P2ry1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased platelet aggregation ( J:59055 )
• impaired or delayed platelet aggregation in response to ADP or collagen
• high concentrations of ADP induce aggregation without shape change

homeostasis/metabolism
decreased platelet aggregation ( J:59055 )
• impaired or delayed platelet aggregation in response to ADP or collagen
• high concentrations of ADP induce aggregation without shape change
decreased susceptibility to induced thrombosis ( J:59055 )
• resistant to acute thrombosis following administration of ADP or collagen and epinephrine




Genotype
MGI:3054529
ht2
Allelic
Composition		 P2ry1tm1Gac/P2ry1+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2ry1tm1Gac mutation (1 available); any P2ry1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased platelet aggregation ( J:59055 )
• decreased platelet aggregation in response to ADP or collagen

homeostasis/metabolism
decreased platelet aggregation ( J:59055 )
• decreased platelet aggregation in response to ADP or collagen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory