About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tox)1Kay
transgene insertion 1, Jonathan Kaye
MGI:2181728
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Tox)1Kay/?
Toxtm1.1Kay/Toxtm1.1Kay 		involves: 129S6/SvEvTac * C57BL/6 MGI:3807781


Genotype
MGI:3807781
cx1
Allelic
Composition		 Tg(Tox)1Kay/?
Toxtm1.1Kay/Toxtm1.1Kay
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tox)1Kay mutation (0 available)
Toxtm1.1Kay mutation (0 available); any Tox mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell number ( J:131287 )
• transgene expression rescues the reduced number of CD4+ T cells found in the Toxtm1.1Kay homozygotes
• the percentage of thymic single positive CD8+ T cells are enhanced 5-fold compared to wild-type
• in addition, there is a population of CD8+ T cells that are TCRint/hiCD5lo/- which are not found in wild-type mice

hematopoietic system
abnormal T cell number ( J:131287 )
• transgene expression rescues the reduced number of CD4+ T cells found in the Toxtm1.1Kay homozygotes
• the percentage of thymic single positive CD8+ T cells are enhanced 5-fold compared to wild-type
• in addition, there is a population of CD8+ T cells that are TCRint/hiCD5lo/- which are not found in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory