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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tox)1Kay
transgene insertion 1, Jonathan Kaye
MGI:2181728
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Tox)1Kay/?
Toxtm1.1Kay/Toxtm1.1Kay 		involves: 129S6/SvEvTac * C57BL/6 MGI:3807781


Genotype
MGI:3807781
cx1
Allelic
Composition		 Tg(Tox)1Kay/?
Toxtm1.1Kay/Toxtm1.1Kay
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tox)1Kay mutation (0 available)
Toxtm1.1Kay mutation (0 available); any Tox mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell number ( J:131287 )
• transgene expression rescues the reduced number of CD4+ T cells found in the Toxtm1.1Kay homozygotes
• the percentage of thymic single positive CD8+ T cells are enhanced 5-fold compared to wild-type
• in addition, there is a population of CD8+ T cells that are TCRint/hiCD5lo/- which are not found in wild-type mice

hematopoietic system
abnormal T cell number ( J:131287 )
• transgene expression rescues the reduced number of CD4+ T cells found in the Toxtm1.1Kay homozygotes
• the percentage of thymic single positive CD8+ T cells are enhanced 5-fold compared to wild-type
• in addition, there is a population of CD8+ T cells that are TCRint/hiCD5lo/- which are not found in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory