All Phenotypes Egr1<tm1Pch> MGI Mouse

decreased aggression ( J:45064 )

• males do not display aggression towards other males

abnormal sexual interaction ( J:45064 )

• males lacked sex drive

oligozoospermia ( J:45064 )

decreased somatotroph cell number ( J:45064 )

• 2-fold decrease in the proportion of somatotrophs

adenohypophysis hypoplasia ( J:45064 )

• size reduction of the anterior pituitary

• posterior pituitary appeared normal

• normal proportion of corticotrophs

• normal proportion of lactotrophs

small prostate gland ( J:45064 )

small seminal vesicle ( J:45064 )

• the size of the seminal gland and the amount of seminal fluid are reduced

• however, the epididymis is normal

absent corpus luteum ( J:45064 )

absent mature ovarian follicles ( J:45064 )

• small antral follicles that do not mature

small seminiferous tubules ( J:45064 )

decreased Leydig cell number ( J:45064 )

• reduced number of Leydig cells in 12 week old mutant males

decreased testis weight ( J:45064 )

• 38% reduction in weight at 5 months of age relative to wild-type

abnormal pituitary secretion ( J:45064 )

• LH was undetected at 2 weeks of age

• normal prolactin level in pituitary

decreased body size ( J:45064 )

decreased body weight ( J:45064 )

• 20% decrease in body weight relative to wild-type adults

• weight was similar to that of wild-type at birth

postnatal growth retardation ( J:45064 )

decreased circulating testosterone level ( J:45064 )

• serum testosterone levels in 4 - 6 week old homozygous maless were 0.30 +/- 0.03 ng/ml compared to 0.72 +/- 0.12 ng/ml in wild-type mice

decreased growth hormone level ( J:45064 )

• 4-fold decrease of growth hormone (GH) in pituitary of 2 week old males

• 2.5-fold decrease of GH in pituitary of 2-4 month old males

• 3-fold decrease of GH in pituitary of females

oligozoospermia ( J:45064 )

small prostate gland ( J:45064 )

small seminal vesicle ( J:45064 )

• the size of the seminal gland and the amount of seminal fluid are reduced

• however, the epididymis is normal

absent corpus luteum ( J:45064 )

absent mature ovarian follicles ( J:45064 )

• small antral follicles that do not mature

small seminiferous tubules ( J:45064 )

decreased Leydig cell number ( J:45064 )

• reduced number of Leydig cells in 12 week old mutant males

decreased testis weight ( J:45064 )

• 38% reduction in weight at 5 months of age relative to wild-type

abnormal endometrium morphology ( J:45064 )

• abnormal longitudinal and circular layers

small uterus ( J:45064 )

anovulation ( J:45064 )

• failure to ovulate that is not rescued by LH injection

female infertility ( J:45064 )

• LH injection did not rescue female infertiltiy

male infertility ( J:45064 )

• one wild-type female was successfully impregnated by a mutant male; however all others failed to plug females in estrus

• injection of lutenizing hormone (LH) restored fertility in approximately 50% of males