Phenotypes associated with this allele

• Allele Symbol: Nfatc1^tm1Mak
• Allele Name: targeted mutation 1, Tak W Mak
• Allele ID: MGI:2181766
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfatc1^tm1Mak/Nfatc1^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:3700991

Genotype
MGI:3700991

hm1

• Allelic Composition: Nfatc1^tm1Mak/Nfatc1^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:46399 )

• homozygotes die by E14.5, from cardiac failure

cardiovascular system

abnormal cardiac outflow tract development ( J:46399 )

• proximal region of outflow tract is stenotic

abnormal mitral valve development ( J:46399 )

• mitral valve is primitive and has no well defined leaflets at E13.5

abnormal tricuspid valve development ( J:46399 )

• tricuspid valve is primitive and has no well defined leaflets at E13.5

abnormal semilunar valve development ( J:46399 )

• semilunar valves are underdeveloped at E13.5

abnormal mitral valve cusp morphology ( J:46399 )

• mitral valve leaflets are not well defined at E13.5

abnormal tricuspid valve cusp morphology ( J:46399 )

• tricuspid valve leaflets are not well defined at E13.5

abnormal interventricular septum morphology ( J:46399 )

• interventricular foramen is still present in most mutants are E13.5

cardiac hypertrophy ( J:46399 )

• ventricular walls are hypertrophied at E12.5

hematopoietic system

anemia ( J:46399 )

• by E12.5, 50% of embryos display anemia

homeostasis/metabolism

edema ( J:46399 )

• by E12.5, 50% of embryos are edematous

embryo

embryo tissue necrosis ( J:46399 )

• abdominal necrosis at E12.5

growth/size/body

cardiac hypertrophy ( J:46399 )

• ventricular walls are hypertrophied at E12.5