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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cbx2tm1Ykf
targeted mutation 1, Yuko Katoh-Fukui
MGI:2181776
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cbx2tm1Ykf/Cbx2tm1Ykf involves: 129S2/SvPas * C57BL/6NJcl MGI:3040510
ht2
Cbx2tm1Ykf/Cbx2+ involves: 129S2/SvPas * C57BL/6NJcl MGI:3040603


Genotype
MGI:3040510
hm1
Allelic
Composition
Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic
Background
involves: 129S2/SvPas * C57BL/6NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbx2tm1Ykf mutation (6 available); any Cbx2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 40% survive at least until 6 weeks of age
• 60% die between 8 and 30 days of age

craniofacial
• low body weight attributed in part to dental occlusion

digestive/alimentary system
• low body weight attributed in part to partial colon obstruction

endocrine/exocrine glands
• characteristic of 87% of XX mice
• characteristic of 13% of XX mice

growth/size/body
• low body weight attributed in part to dental occlusion
• a few days after birth pups weigh 26% of littermate control weight

reproductive system
• characteristic of 87% of XX mice
• characteristic of 13% of XX mice
• 50% of XY mice had both ovarian and testicular tissue
• 50% of XY mice had only ovaries

skeleton
• low body weight attributed in part to dental occlusion
• homeotic transformations are seen over the entire axis; six rather than seven vertebrosternal ribs develop,fusion of exoccipital to proatlas with first cervical vertebra becoming equivalent to C2, C6 or C7 becomes first thoracic vertebra,lumbar vertebra L5 or L6 becomes the first sacral vertebra




Genotype
MGI:3040603
ht2
Allelic
Composition
Cbx2tm1Ykf/Cbx2+
Genetic
Background
involves: 129S2/SvPas * C57BL/6NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbx2tm1Ykf mutation (6 available); any Cbx2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• low frequency of posterior axis transformations





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory